Results 111 to 120 of about 17,224 (237)

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Anaerobe‐Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Genital microbiome dysbiosis is an important risk factor for the sexual acquisition of human immunodeficiency virus (HIV) in both the male and female genital tracts. The vaginal, penile and urethral mucosae are distinct microenvironments with characteristic microbiome compositions.
Shirley Constable, Yasamin Minazadeh, Lane B. Buchanan, Henryroger Ssemunywa, Ronald M. Galiwango, Rupert Kaul, Jessica L. Prodger   +6 more
wiley   +1 more source

Epistasis between FLG and IL4R genes on the risk of allergic sensitization: results from two population-based birth cohort studies [PDF]

, 2018
Immune-specifc genes as well as genes responsible for the formation and integrity of the epidermal barrier have been implicated in the pathogeneses of allergic sensitization.
A Benedetto De, A Custovic, A Kubo, AD Irvine, AE Kelly-Welch, AH Ziyab, B Omolo, CN Palmer, D Vercelli, DE Comings, DP Potaczek, F Castro-Giner, G Roberts, HF Bunn, IH Chan, K Adjers, K Bonnelykke, LS Penrose, M Granada, M Kabesch, MJ Loza, N Soto-Ramirez, O Zuk, P Cummings, P Kraft, PM Salo, RA Oord van den, S Olson, S Weidinger, SL Zeger, TM Baye, W Pan, WH Wei, WW Busse, X Liu, Y Benjamini, YI Wan   +36 more
core   +2 more sources

Age‐dependent reductions in natural moisturizing factor and caspase‐14 in paediatric atopic dermatitis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Risa Fukuda, Kyongsun Pak, Hazuki Yasuda, Tomoko Kawai, Kenichiro Hata, Naoko Mochimaru, Marie Takenouchi, Ryo Tanaka, Rena Hashimoto, Yuhki Ueda, Susumu Hashimoto, Keisuke Shimazaki, Kazue Yoshida   +12 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells [PDF]

, 2016
Background Mutations in the gene encoding filaggrin (FLG), an epidermal structural protein, are the strongest risk factor identified for the development of atopic dermatitis (AD).
Andrew J. Muinonen-Martin, Angelova-Fischer, Banchereau, Bashir, Berth-Jones, Brown, Chu, Claire S. Leitch, Correale, Cunjing Yu, Dahl, Di Gennaro, Eenass Natafji, Elias, Gibbs, Gibbs, Gibbs, Gilmour, Gilmour, Harriott-Smith, Jürgen Schwarze, Kammeyer, Kammeyer, Kaneko, Kezic, Laihia, Leung, Linda E. Campbell, Loffler, McAleer, McGrath, Meunier, Nayani Madarasingha, Norval, Pasanen, Pasanen, Paul M. Fitch, Peltonen, Pinnagoda, Prechtel, Richard B. Weller, Roland Chu, Romani, Romani, Ross, Sadhu, Sarah E.M. Howie, Seneschal, Sergeant, Sharizan Abdul-Ghaffar, Shibaki, Smith, W.H. Irwin McLean, Williams, Yoshida, Zoë C. Venables   +55 more
core   +4 more sources

Contact Sensitization in Adults With Atopic Dermatitis: A 21‐Year Single‐Center Tertiary Experience

Contact Dermatitis, Volume 94, Issue 5, Page 465-474, May 2026.
A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Francesca Caroppo, Anna Zambello, Giulia Biolo, Fortunato Cassalia, Laura Ventura, Anna Belloni Fortina   +5 more
wiley   +1 more source

Excessive gestational weight gain and risk of asthma, rhinitis and allergic sensitization: Results from a Portuguese birth cohort

Pediatric Allergy and Immunology, Volume 37, Issue 5, May 2026.
Abstract Background Maternal body mass index (BMI) before pregnancy and gestational weight gain (GWG) have been implicated in offspring health, yet their specific impact on the development of allergic diseases remains unclear. We aimed to evaluate associations between pre‐pregnancy BMI and GWG with asthma, rhinitis, eczema, food allergy, anaphylaxis ...
Mónica Rodrigues, Susana Santos, Francisca Castro Mendes, Pedro Moreira, André Moreira   +4 more
wiley   +1 more source

Filaggrin Mutations and Allergic Contact Sensitization [PDF]

Journal of Investigative Dermatology, 2008
In this issue, Novak et al. (2008) provide evidence that filaggrin barrier defects might also predispose to allergic contact dermatitis by allowing greater penetration of chemical haptens. Their report provides a fresh perspective on the issues of contact allergy, nickel sensitization, and stratum corneum defects.
openaire   +2 more sources

Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis

European Journal of Histochemistry
This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins.
Shicheng Jiao, Lijun Deng, Mu Niu, Jie Yang   +3 more
doaj   +1 more source