Feeding filaggrin: effects of L-histidine supplementation in atopic dermatitis
Clinical, Cosmetic and Investigational Dermatology, 2017 Siao Pei Tan,1,2 Simon B Brown,1,2 Christopher EM Griffiths,3 Richard B Weller,1,2 Neil K Gibbs3,4 1MRC Centre for Inflammation Research, 2Department of Dermatology, The University of Edinburgh, Edinburgh, 3Dermatology Centre, Division of Musculoskeletal
Tan SP +4 more
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HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs. [PDF]
, 2019 Maintenance of high-turnover tissues such as the epidermis requires a balance between stem cell proliferation and differentiation. The molecular mechanisms governing this process are an area of investigation.
Chen, Yifang +8 more
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Journal of Allergy and Clinical Immunology: GlobalBackground: Previous studies have determined that up to 6% of patients with aspirin-exacerbated respiratory disease (AERD) have family history of AERD, indicating a possible link with genetic polymorphisms.
Elina Jerschow, MD, MSc +8 more
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Summary of single nucleotide polymorphisms in filaggrin associated with atopic dermatitis
JEADV Clinical PracticeBackground Loss of function mutations in the filaggrin gene (FLG) play an important role in the pathogenesis of atopic dermatitis (AD). However, FLG is structurally challenging to sequence using conventional high‐throughput techniques.
Rachita Pandya +8 more
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Acta Dermato-Venereologica, 2017 Atopic dermatitis (AD) is a chronic inflammatory skin disease. Corticosteroids, which are widely used for AD treatment, have adverse effects, and alternative treatments are urgently needed.
Kiyoko Yamada +3 more
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Acta Dermato-VenereologicaThe World Allergy Organization recommends probiotics in the prevention of atopic dermatitis in high-risk populations. Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermatitis through disruption of the skin keratin layer ...
Dinastry Pramadita Zakiudin +5 more
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Variation in the activities of late stage filaggrin processing enzymes, calpain-1 and bleomycin hydrolase, together with pyrrolidone carboxylic acid levels, corneocyte phenotypes and plasmin activities in non-sun-exposed and sun-exposed facial stratum corneum of different ethnicities [PDF]
, 2016 BACKGROUND: Knowledge of the ethnic differences and effects of photodamage on the relative amounts of natural moisturizing factor (NMF) together with filaggrin processing enzymes in facial stratum corneum is limited.
Lane, ME +5 more
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Loss of ceramide synthase 3 causes lethal skin barrier disruption [PDF]
, 2017 The stratum corneum as the outermost epidermal layer protects against exsiccation and infection. Both the underlying cornified envelope (CE) and the intercellular lipid matrix contribute essentially to these two main protective barriers. Epidermis-unique
Bayerle, Aline +14 more
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Could Inflammaging and Its Sequelae Be Prevented or Mitigated? [PDF]
, 2019 Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular ...
Elias, Peter M, Man, Mao-Qiang
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Immunohistochemistry studies on bovine squamous cell carcinoma morphological characterization of epidermal cell proliferation and differentiation markers and characterization of cytokeratins [PDF]
, 2001 Bovine Ocular Squamous Cell Carcinoma (OSCC) is a general designation for a group of primary neoplasias of keratinocytes arising from ocular tissues, especially the lids and particularly the third eye lid. OSCC has been diagnosed all over the world with
Carvalho, T. +6 more
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