Results 281 to 290 of about 21,702 (299)

Filaggrin and Skin Infections

2014
The skin forms an important physical and immune barrier against microbes. Filaggrin, one of the key components of the stratum corneum, is now increasingly known to be the driving force in a wide range of metabolic, immune, and inflammatory processes of the skin barrier.
Sophie C. S. Cai, Emily Yiping Gan, Mark B Y Tang   +2 more
openaire   +2 more sources

Filaggrin gene mutations in relation to contact allergy and hand eczema in adolescence

Contact Dermatitis, 2019
Filaggrin is an important protein for structure and function of the skin barrier. Filaggrin gene (FLG) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis.
M. Lagrelius, C. Wahlgren, M. Bradley, E. Mélen, I. Kull, A. Bergström, C. Lidén   +6 more
semanticscholar   +1 more source

Differential patterns of filaggrin expression in lamellar ichthyosis

British Journal of Dermatology, 1998
Lamellar ichthyosis (LI) is a rare genetic and congenital disturbance of keratinization that is phenotypically and genotypically heterogeneous. Filaggrin is one of the major components of the stratum corneum situated in the protein matrix and the cornified envelope.
Valle, GarcÍA Salgado, Becker, Unamuno PÉrez, Peña Penabad, PÉrez Arellano, Gutierrez De Diego   +6 more
openaire   +4 more sources

Palmar hyperlinearity in early childhood atopic dermatitis is associated with filaggrin mutation and sensitization to egg

Pediatric dermatology, 2019
Palmar hyperlinearity is a typical clinical feature of Filaggrin gene (FLG) null mutations. There are reports of FLG mutations and allergic sensitization; however, reports on the relationship between palmar hyperlinearity to sensitization are limited ...
Tatsuki Fukuie, Ryuhei Yasuoka, T. Fujiyama, J. Sakabe, Tomohide Taguchi, Y. Tokura   +5 more
semanticscholar   +1 more source

Expression of filaggrin-2 protein in the epidermis of human skin diseases: A comparative analysis with filaggrin

Biochemical and Biophysical Research Communications, 2014
Filaggrin-2 is a member of the S100 fused-type protein family, and the structural features and expression of filaggrin-2 are similar to those of profilaggrin, a protein essential for keratinization. In the present study, we investigated the expression profile of filaggrin-2 in patients with skin diseases using antibodies against the repetitive region ...
Megumi Mizawa, Mikiro Takaishi, Tadamichi Shimizu, Takako Yamakoshi, Teruhiko Makino   +4 more
openaire   +2 more sources

Nickel reactivity and filaggrin null mutations - evaluation of the filaggrin bypass theory in a general population

Contact Dermatitis, 2010
It was recently shown that filaggrin null mutation carrier status was associated with nickel allergy and self-reported intolerance to costume jewellery. Because of the biochemical characteristics of filaggrin, it may show nickel barrier properties in the stratum corneum.To investigate whether subjects with filaggrin null mutations report nickel ...
Ross-Hansen, Katrine, Menné, Torkil, Johansen, Jeanne D, Carlsen, Berit C, Linneberg, Allan, Nielsen, Niels H, Stender, Steen, Meldgaard, Michael, Szecsi, Pal B, Thyssen, Jacob P   +9 more
openaire   +4 more sources

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Nature Genetics, 2006
C. Palmer, A. Irvine, A. Terron-Kwiatkowski, Yiwei Zhao, H. Liao, Simon P. Lee, D. Goudie, A. Sandilands, L. Campbell, F. Smith, G. O'Regan, R. Watson, Joanne E. Cecil, S. Bale, J. Compton, J. DiGiovanna, J. DiGiovanna, P. Fleckman, S. Lewis-jones, G. Arseculeratne, A. Sergeant, C. Munro, B. E. Houate, K. McElreavey, L. Halkjaer, H. Bisgaard, S. Mukhopadhyay, S. Mukhopadhyay, W. McLean   +28 more
semanticscholar   +1 more source

Pyridoxine stimulates filaggrin production in human epidermal keratinocytes

Molecular Biology Reports, 2021
M. Fujishiro, S. Yahagi, Shota Takemi, Mio Nakahara, T. Sakai, I. Sakata   +5 more
semanticscholar   +1 more source

Filaggrin, the Skin Barrier, and Diabetes

2014
Diabetes is a prevalent disease with a remarkably amount of skin involvement. About 30 % of patients have dermatological manifestations, and these can be the first sign of the disease.
openaire   +2 more sources

Filaggrin and the great epidermal barrier grief

Australasian Journal of Dermatology, 2008
SUMMARYOne of the principal functions of human skin is to form an effective mechanical barrier against the external environment. This involves the maturation and death of epidermal keratinocytes as well as the assembly of a complex network of differentially and spatially expressed proteins, glycoproteins and lipids into the keratinocyte cell membrane ...
openaire   +4 more sources