Acta Dermato-Venereologica, 2017 Epidermal filaggrin level is affected by ultraviolet B irradiation in animal and experimental models. This study examined the effect of ultraviolet B irradiation on epidermal filaggrin and natural moisturizing factors in vivo in healthy adults (n = 22 ...
Stine Simonsen +4 more
doaj +1 more source
Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]
, 2020 Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M +12 more
core
Human and computational models of atopic dermatitis:A review and perspectives by an expert panel of the International Eczema Council [PDF]
, 2018 Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic comorbidities representing a significant burden on patients, their families, and society. Therapeutic options for AD remain limited, in part because of a lack of well-
Bieber, Thomas +15 more
core +6 more sources
Allergy, EarlyView.ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki +6 more
wiley +1 more source
Journal of the Royal College of Physicians of Edinburgh, 2008 Recent genetic findings demonstrate an important role for the epidermal protein filaggrin in the aetiology of atopic diseases, including asthma as well as eczema. Filaggrin is critical to the conversion of keratinocytes to the protein/lipid squames that compose the stratum corneum, the outermost barrier layer of the skin.
null R Weller, null WHI McLean
openaire +1 more source
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
Scientific Reports, 2017 Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology.
Leonie Wallmeyer +6 more
doaj +1 more source
Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. [PDF]
PLoS ONE, 2012 BackgroundFilaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease.
Charlotte Giwercman Carson +4 more
doaj +1 more source
Organ culture and Reflectance Confocal Microscopy as new integrated tools for barrier rescue studies in inflammatory skin diseases [PDF]
, 2015 Here we present a new integrated approach to understand skin barrier recovery after physical (tape stripping, TS) or chemical (SDS) injury by combining human skin organ culture and Reflectance Confocal Microscopy (RCM).
Ciardo, Silvana +9 more
core +1 more source
An 11‐Month‐Old Infant With Unusual Diaper Dermatitis
JEADV Clinical Practice, EarlyView.
Majda Chaoui +2 more
wiley +1 more source
A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations
International Journal of Cosmetic Science, EarlyView.Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos +3 more
wiley +1 more source