Results 131 to 140 of about 6,491,911 (254)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Contact Sensitization in Adults With Atopic Dermatitis: A 21‐Year Single‐Center Tertiary Experience

Contact Dermatitis, Volume 94, Issue 5, Page 465-474, May 2026.
A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Francesca Caroppo, Anna Zambello, Giulia Biolo, Fortunato Cassalia, Laura Ventura, Anna Belloni Fortina   +5 more
wiley   +1 more source

CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo [PDF]

, 2018
Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling molecule, Caspase Recruitment Domain-Containing Protein 14 (CARD14), have been associated with an increased susceptibility to psoriasis but the physiological impact of ...
Cheng, Phil, Contassot, Emmanuel, French, Lars E, Kiefer, Betina, Meier, Barbara, Mellett, Mark, Mohanan, Deepa, Nobbe, Stephan, Ospelt, Caroline, Satoh, Takashi K, Schairer, Rebekka, Thome, Margot   +11 more
core   +1 more source

Excessive gestational weight gain and risk of asthma, rhinitis and allergic sensitization: Results from a Portuguese birth cohort

Pediatric Allergy and Immunology, Volume 37, Issue 5, May 2026.
Abstract Background Maternal body mass index (BMI) before pregnancy and gestational weight gain (GWG) have been implicated in offspring health, yet their specific impact on the development of allergic diseases remains unclear. We aimed to evaluate associations between pre‐pregnancy BMI and GWG with asthma, rhinitis, eczema, food allergy, anaphylaxis ...
Mónica Rodrigues, Susana Santos, Francisca Castro Mendes, Pedro Moreira, André Moreira   +4 more
wiley   +1 more source

In Vitro Anti-Inflammatory and Skin Moisturizing Properties (Levl.) Hand.-Mazz. Extracts

Natural Product Communications, 2020
The in vitro anti-inflammatory and skin moisturizing activities of Pilea martini (Levl.) Hand.-Mazz. were investigated on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and human immortalized keratinocytes.
Jieun Choi, Young Yun Jung, In Jin Ha, Seung Ho Baek, Zhiyun Zhang, Soo-Yong Kim, Yejin Hong, Sungyoon Kim, Hye Won Yeum, Sae-Rom Jeon, Kyungbok Park, Dongwoo Nam   +11 more
doaj   +1 more source

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]

, 2020
Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M, Cau, Laura, Dupont, Christopher L, Gallo, Richard L, Horswill, Alexander R, Hovnanian, Alain, Kaul, Drishti, Khalil, Shadi, Sanford, James A, Wang, Yichen, Williams, Michael R, Zaramela, Livia S, Zengler, Karsten   +12 more
core  

Intrinsic structural disorder in cytoskeletal proteins. [PDF]

, 2013
Cytoskeleton, the internal scaffold of the cell, displays an exceptional combination of stability and dynamics. It is composed of three major filamentous networks, microfilaments (actin filaments), intermediate filaments (neurofilaments), and ...
Beata Szabo, Mainak Guharoy, Peter Tompa, Sara Contreras Martos, Simone Kosol   +4 more
core   +1 more source

Novel Biomarker for Rheumatoid Arthritis: Serum Peptidylarginine Deiminase 4‐Potentiating Activity in an Anti‐Citrullinated Protein Antibody‐Positive At‐Risk Population

Scandinavian Journal of Immunology, Volume 103, Issue 5, May 2026.
In an ACPA‐positive at‐risk RA cohort, serum PAD4‐potentiating activity was measured by HPLC. PAD4act‐positivity identified a subgroup that progressed to clinical arthritis significantly faster, independent of baseline inflammatory markers. Moreover, individuals with high PAD4act more often carried HLA‐DRB shared epitope alleles, a common genetic risk ...
Marta Kaminska, Vijay Joshua, Ewa Bielecka, Tomasz Kantyka, Maja Chrobak, Karin Lundberg, Aase Hensvold, Jan Potempa, Piotr Mydel   +8 more
wiley   +1 more source

Atopic dermatitis: a mini review on pathology and treatment modalities [PDF]

Exploration of Asthma & Allergy
The symptoms of atopic dermatitis (AD), a chronic, recurrent inflammatory skin condition, include immunological dysregulation, severe pruritus, and malfunctioning of the epidermal barrier.
Amrita Sahu, Remya Sreedhar, Somasundaram Arumugam   +2 more
doaj   +1 more source

Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases [PDF]

, 2018
Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a small protein localized
Carnero Moya, Amancio, García Heredia, José Manuel   +1 more
core   +1 more source