Results 211 to 220 of about 6,491,911 (254)
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Journal of Structural Biology, 1990
We have used immunoelectron microscopy to map the biosynthetic pathways of loricrin and filaggrin in epidermal keratinocytes at successive stages of differentiation in newborn mouse skin. The filaggrin epitope is first detected in large, irregularly shaped, keratohyalin granules (F-granules) in the stratum granulosum, and then distributed throughout ...
A. Steven +3 more
semanticscholar +3 more sources
We have used immunoelectron microscopy to map the biosynthetic pathways of loricrin and filaggrin in epidermal keratinocytes at successive stages of differentiation in newborn mouse skin. The filaggrin epitope is first detected in large, irregularly shaped, keratohyalin granules (F-granules) in the stratum granulosum, and then distributed throughout ...
A. Steven +3 more
semanticscholar +3 more sources
Is filaggrin really a filament-aggregating protein in vivo?
Archives of Dermatological Research, 1993Filaggrin, a basic protein of the stratum corneum, was named as such because of its capability to aggregate keratin intermediate filaments in vitro. To investigate its filament-aggregating capability in vivo, we performed immunoelectron microscopy in three autosomal dominant genodermatoses serving as in vivo models of abnormalities of keratin filament ...
B, Weidenthaler +2 more
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Characterization of a phosphorylated form of the intermediate filament-aggregating protein filaggrin
Biochemistry, 1982Filaggrin and a phosphorylated form of filaggrin, which has been shown by pulse-chase studies to be a precursor form of the protein [Dale, B. A., & Ling, S. Y. (1979) Biochemistry 18, 3539-3546], were compared for functional, biochemical, and physical properties. Filaggrin reacts with keratin filaments to form visible macrofibrils, unlike the precursor
J D, Lonsdale-Eccles +2 more
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Characterization of canine filaggrin: gene structure and protein expression in dog skin
Veterinary Dermatology, 2013Background – Filaggrin (FLG) is a key protein for skin barrier formation and hydration of the stratum corneum. In humans, a strong association between FLG gene mutations and atopic dermatitis has been reported. Although similar pathogenesis and clinical manifestation have been argued in canine atopic dermatitis, our understanding of canine FLG is ...
Satoko, Kanda +6 more
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Pathology - Research and Practice, 1989
The epithelia lining the cyst of five cases of calcifying odontogenic cyst (COC) were evaluated immunohistochemically with the use of monoclonal antibodies (MoAb's) against keratin (PKK1, KL1, K4.62, K8.12) and vimentin, and polyclonal antisera agonist involucrin and filaggrin.
K. Kakudo +5 more
semanticscholar +3 more sources
The epithelia lining the cyst of five cases of calcifying odontogenic cyst (COC) were evaluated immunohistochemically with the use of monoclonal antibodies (MoAb's) against keratin (PKK1, KL1, K4.62, K8.12) and vimentin, and polyclonal antisera agonist involucrin and filaggrin.
K. Kakudo +5 more
semanticscholar +3 more sources
Altered expression of S100 fused‐type proteins in an atopic dermatitis skin model
Experimental Dermatology, 2023Atopic dermatitis (AD) is a chronic inflammatory skin disorder with elevated interleukin (IL)‐4 and IL‐13 signatures and extensive barrier dysfunction, which is correlated with the downregulation of filaggrin (FLG). FLG is a member of the S100 fused‐type
T. Makino +4 more
semanticscholar +1 more source
Journal of Molecular Biology, 1983
The urea-soluble protein profiles of guinea pig, rat, mouse and human epidermis have been compared by non-equilibrium pH gradient/sodium dodecyl sulphate two-dimensional gel electrophoresis. The histidine-rich proteins (filaggrins) were identified firstly by their characteristic specificity and kinetics of labelling with [3H]histidine and [32P ...
C R, Harding, I R, Scott
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The urea-soluble protein profiles of guinea pig, rat, mouse and human epidermis have been compared by non-equilibrium pH gradient/sodium dodecyl sulphate two-dimensional gel electrophoresis. The histidine-rich proteins (filaggrins) were identified firstly by their characteristic specificity and kinetics of labelling with [3H]histidine and [32P ...
C R, Harding, I R, Scott
openaire +2 more sources
International Journal of Biological Macromolecules
The integrity of the skin barrier is essential for maintaining skin health, with the stratum corneum and filaggrin 2 (FLG-2) playing a key role. FLG-2 deficiency or mutation has been linked to diseases such as atopic dermatitis, while external stressors ...
Zhaoyang Wang +10 more
semanticscholar +1 more source
The integrity of the skin barrier is essential for maintaining skin health, with the stratum corneum and filaggrin 2 (FLG-2) playing a key role. FLG-2 deficiency or mutation has been linked to diseases such as atopic dermatitis, while external stressors ...
Zhaoyang Wang +10 more
semanticscholar +1 more source
Antibodies Against Citrullinated Proteins and Filaggrin
2014Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints. Rheumatoid arthritis is diagnosed by its clinical features, radiography, and serological tests. An important serological test is the determination of antibodies against citrullinated proteins (ACPA).
Katleen F. E. Van Steendam +1 more
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Allergy. European Journal of Allergy and Clinical Immunology, 2019
Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance.
S. Rahrig +10 more
semanticscholar +1 more source
Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance.
S. Rahrig +10 more
semanticscholar +1 more source