Results 171 to 180 of about 55,996 (210)

CarpeDeam: a de novo metagenome assembler for heavily damaged ancient datasets. [PDF]

Genome Biol
Kraft L, Söding J, Steinegger M, Jochheim A, Wad Sackett P, Fernandez-Guerra A, Renaud G.   +6 more
europepmc   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

SPARFlow: a KNIME workflow for integrated structure-activity or structure-property relationship analysis. [PDF]

J Cheminform
Abreu-Martínez EE, Martinez-Mayorga K, Merino G.   +2 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

OBIMD: A Multi-modal Dataset for Contextual Interpretation of Oracle Bone Inscriptions. [PDF]

Sci Data
Li B, Yang J, Liang Y, Hu X, Ding Z, Peng X, Han S, Qin P, Luo D, Jin T, Gao F, Liu Y, Ji R.   +12 more
europepmc   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Exploration of a workflow for the classification and identification of co-purified protein complexes yields new structures and multiple MSP assembly states. [PDF]

PLoS One
Zhang Q, Murthy AV, Mim C.
europepmc   +1 more source

Evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulations. [PDF]

Genome Biol
Lefeuvre M, Marsolier MC, Bon C.
europepmc   +1 more source

Molecular characterization and genotypic diversity of human astroviruses among patients with gastroenteritis in Saudi Arabia, 2022-2023. [PDF]

Virus Genes
Alqahtani S, Awadalla M, Alanazi AE, Alhumaidy AA, Hanif A, Alshehri HA, Alsayegh AA, AlQusi F, Alshanbari HM, Eifan S, Alosaimi B.   +10 more
europepmc   +1 more source