Results 91 to 100 of about 1,129,799 (283)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A Majority of Family Physicians Use a Hospitalist Service When Their Patients Require Inpatient Care

Journal of Primary Care & Community Health, 2015
Background: The hospitalist movement in the United States has risen in prominence over the past 2 decades with more physicians practicing as hospitalists.
Douglas Ivins, Brenna Blackburn, Lars E. Peterson, Warren P. Newton, James C. Puffer   +4 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Toward Secure and Scalable Digital Evidence Preservation: A Blockchain-Driven Framework

Blockchains
Digital evidence management systems are designed to ensure that the digital evidence is genuine and effectively handle its complexity. In this work, blockchain technology is applied to handle the digital evidence by introducing several layers of security
Areej Dweib, Fadi Abu-Amara, Muath Alrammal   +2 more
doaj   +1 more source

File fragment encoding classification—An empirical approach

Digital Investigation, 2013
Over the past decade, a substantial effort has been put into developing methods to classify file fragments. Throughout, it has been an article of faith that data fragments, such as disk blocks, can be attributed to different file types. This work is an attempt to critically examine the underlying assumptions and compare them to empirically collected ...
Vassil Roussev, Candice Quates
openaire   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A Global Dataset Mapping the AI Innovation from Academic Research to Industrial Patents

Scientific Data
In the rapidly evolving field of artificial intelligence (AI), mapping innovation patterns and understanding effective technology transfer from research to applications are essential for economic growth. However, existing data infrastructures suffer from
Haixing Gong, Hui Zou, Xingzhou Liang, Shiyuan Meng, Pinlong Cai, Xingcheng Xu, Jingjing Qu   +6 more
doaj   +1 more source

Using NLP techniques for file fragment classification

Digital Investigation, 2012
Abstract The classification of file fragments is an important problem in digital forensics. The literature does not include comprehensive work on applying machine learning techniques to this problem. In this work, we explore the use of techniques from natural language processing to classify file fragments.
Simran Fitzgerald, George Mathews, Colin Morris, Oles Zhulyn   +3 more
openaire   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source