Results 141 to 150 of about 113,103 (252)

De-novo assembly of 82 bacterial genomes using Nanopore sequencing and prediction of biosynthetic capacity. [PDF]

Sci Data
Basdani D, Zekkas S, Kylonis A, Tzimotoudis D, Fakis G, Felföldi T, Márialigeti K, Boukouvala S.   +7 more
europepmc   +1 more source

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

Population Structure of the Jewel Scarab Chrysina gloriosa. [PDF]

Genome Biol Evol
Sylvester T, Hjelmen CE, Thompson MJ, Blackmon LT, Alfieri JM, Hoover Z, Esfandani T, Blackmon H.   +7 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

FALCON2: compression-based metagenomic classification of ancient viruses. [PDF]

Bioinformatics
Marques LL, Pinho AJ, Pratas D.
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases. [PDF]

Sci Transl Med
Annapragada AV, Foda ZH, Orjuela H, Norton C, Koul S, Niknafs N, Short S, Boyapati K, Bartolomucci A, Mathios D, Noë M, Cherry C, Carey J, Leal A, Chesnick B, Dracopoli NC, Medina JE, Vulpescu NA, Bruhm DC, Bacus S, Adleff V, Kim AK, Baylin SB, Kirk GD, Sorop A, Iacob R, Iacob S, Gheorghe L, Dima S, Ramírez-Zea M, McGlynn KA, Feltoft CL, Johansen JS, Groopman J, Phallen J, Scharpf RB, Velculescu VE.   +36 more
europepmc   +1 more source

Method for Reconstruction of Fragmented Files in Case of Loss of Data on Fragmentation [PDF]

Engineering Journal: Science and Innovation, 2012
openaire   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders. [PDF]

Mil Med Res
Li L, Han Q, Bai HL, Xiao Q, He X, Chen JF, Zhen ZM, Luo XQ, Zhang YJ, Lu MM, Wang X, Li SY, Xiong JX, Wang Y, Hu ZA, Zhang XL, Liu Y, He C.   +17 more
europepmc   +1 more source