Results 101 to 110 of about 1,689,279 (299)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Propuesta organizacional de un archivo de gestión para organizaciones empresariales
Ciência da Informação, 2012 Hoy día la gestión eficaz de los recursos de información y documentación en las empresas, genera la búsqueda de soluciones prácticas y exitosas. El presente artículo aborda el papel fundamental que han tenido los archivos, desde la antigüedad hasta la ...
Irima Campillo Torres Irima +1 more
doaj
L'aplicació de la garantia juvenil a Catalunya [PDF]
Revista d'Estudis Autonòmics i Federals, 2015 The dire situation of unemployed youth between16-25, requires specific and effective actions from public administrations. This article analyzes if the implementation in Catalonia of the Council Recommendation on the establishment of a Youth Guarantee ...
Agnès Pardell Veà +1 more
doaj
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
An enterprise-level naval shipbuilding plan [PDF]
Overview: This paper reviews the past performance of Australian naval shipbuilding, describes the pros and cons of a rolling production model, and unpicks the issues that the government will have to take into account.
Andrew Davies, Mark Thomson
core
Municipal Bankruptcy Under the 1976 Amendments to Chapter IX of the Bankruptcy Act [PDF]
, 1976 This articles examines the new Chapter IX of the Bankruptcy Act, particularly its effectiveness in providing insolvent or financially distressed municipalities with a simpler and more efficient method of obtaining financial relief. The articles discusses
Bond, Kenneth W.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source