Comparison of the Efficacy of Different Doses of Filgotinib in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Based on the RCTs [PDF]
Dose-ResponseObjective This study compared the efficacy of different doses of filgotinib (100 mg vs 200 mg) in the treatment of rheumatoid arthritis (RA). Methods We conducted a systematic review of 4 electronic databases up to January 2025.
Xia Ye +7 more
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Rheumatology and Therapy, 2023 Introduction This post hoc analysis of the phase 3 rheumatoid arthritis (RA) filgotinib clinical trial program assessed the effect of filgotinib on body mass index (BMI) in patients with RA and the impact of BMI on the efficacy and safety of filgotinib ...
Alejandro Balsa +2 more
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Rheumatology and Therapy, 2020 Introduction The Janus kinase (JAK) inhibitor therapeutic class has shown significant clinical benefit in the treatment of rheumatoid arthritis (RA).
Lovely Goyal, Yang Pan, Wangshu Zhang
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Optimal use and cycling strategies of Janus kinase inhibitors in ulcerative colitis: current evidence and clinical implications from the KASID Guidelines Task Force Team [PDF]
Intestinal ResearchJanus kinase (JAK) inhibitors are an important treatment option for ulcerative colitis, providing rapid onset of action, oral administration, and efficacy even after biologic failure. The 3 approved agents—tofacitinib, filgotinib, and upadacitinib—differ
Seung Min Hong +20 more
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A disproportionality analysis of FDA adverse event reporting system (FAERS) events for filgotinib. [PDF]
PLoS ONEBackgroundAlthough filgotinib, a selective Janus kinase 1 inhibitor, has been increasingly applied in the treatment of inflammatory diseases, its comprehensive safety profile remains insufficiently characterized.
Yinli Shi +7 more
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Filgotinib inhibits METTL3-mediated m6A of EIF3A by targeting ERG-TBP to suppress PDAC progression JAK-STAT3-independently [PDF]
npj Precision OncologyPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor. EIF3A has been identified as a reader of N6-methyladenosine (m6A) modification, influencing the translation levels of various molecules and functioning as an oncogene.
Chaolei Zhang +8 more
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Janus kinase 1 inhibitors for treating immune checkpoint inhibitor-induced enterocolitis – report of two filgotinib-treated cases and literature review [PDF]
Acta OncologicaBackground and purpose: Treatment of cancer with immune checkpoint inhibitors (ICIs) entails a risk of immune-related adverse events (irAEs). Data on the treatment of immune-related enterocolitis (irEC) in patients with inadequate symptom control after ...
Henrik Ekedahl +5 more
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Rheumatoid Arthritis Preceded by Interstitial Lung Disease Controlled by Long‐Term Treatment With the Janus Kinase 1‐Selective Inhibitor, Filgotinib: A Case Report [PDF]
Respirology Case ReportsWe present a case of active interstitial lung disease (ILD) preceding the onset of rheumatoid arthritis (RA). A 68‐year‐old man had dyspnea, decreased forced vital capacity, and elevated Krebs von den Lungen‐6 levels.
Takeo Sato +4 more
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Clinical and Experimental Gastroenterology, 2022 Arianna Dal Buono,1 Roberto Gabbiadini,1 Virginia Solitano,1,2 Edoardo Vespa,1,2 Tommaso Lorenzo Parigi,1,2 Alessandro Repici,2,3 Antonino Spinelli,1,2,4 Alessandro Armuzzi1,2 1IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy ...
Arianna Dal Buono +2 more
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Immune‐Mediated Thrombocytopenia in an Ulcerative Colitis Patient After Initiating Filgotinib Treatment: A Case Report [PDF]
Clinical Case ReportsModerate‐to‐severe ulcerative colitis can be effectively treated with JAK‐1 inhibition, but platelet counts should be closely monitored, especially in active disease.
M. J. van derHoff +2 more
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