Results 41 to 50 of about 1,834,623 (303)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Evaluating the Relationship Between Patients Diagnosed with Anxiety and Depression and Rates of Postoperative Opioid Use in Five of the Most Common Hand Surgeries

Journal of Hand Surgery Global Online
Purpose: This study compared postoperative opioid utilization between patients with and without preoperative diagnoses of anxiety and/or depression undergoing elective upper-extremity surgery. We hypothesized that patients with these diagnoses would fill
Martinus Megalla, MD, Zachary T. Grace, MD, Matthew J. Solomito, PhD, MS, Brian T. Ford, MD, Nicholas A. Bontempo, MD   +4 more
doaj   +1 more source

Suppression of Phase Separation in LiFePO4 Nanoparticles During Battery Discharge

, 2011
Using a novel electrochemical phase-field model, we question the common belief that LixFePO4 nanoparticles separate into Li-rich and Li-poor phases during battery discharge.
Allen S. M., Amine K., Armand M., Aziz M. J., Balluffi R. W., Bazant M. Z., Bockris J. O. M., Branicio P. S., Burch D., Cahn J. W., Chen G. Y., Chung S. Y., Daniel A. Cogswell, Dargaville S., Delmas C., Dreyer W., Dupre N., Granasy L., Guyer J. E., Han B. C., Huang H., Huggins R. A., Islam M. S., Kang B., Kao Y. H., Karma A., Kuwahara A., Laffont L., Leriche J. B., Malik R., Malik R., Martin Z. Bazant, Meethong N., Meethong N., Morgan D., Murau P., Nauman E. B., Newman J. S., Padhi A. K., Pasquali M., Peng Bai, Ramana C. V., Ravet N., Ravet N., Shenouda A. Y., Singh G. K., Srinivasan V., Tan H. J., Tang M., Tang M., Tarascon J. M., Van der Ven A., Wang C. S., Whittingham M. S., Wu X. L., Yamada A., Yamada A., Zhu Y. J.   +57 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of an Intelligent Monitoring System for Settlement Prediction of High-Fill Subgrade

Infrastructures
There is currently no mature calculation theory to accurately predict the settlement of high-fill subgrade. This paper developed an intelligent monitoring system to accurately predict the settlement of high-fill subgrade based on on-site experiments, and
Manhong Liao, Kai Wang, Xin Zhou, Liang Tian, Junxin Wang, Haopeng Zhang, Yunchuan Du, Enhui Yang   +7 more
doaj   +1 more source

Optimal Manufacturing-Remanufacturing Production Policy for a Closed-Loop Supply Chain under Fill Rate and Budget Constraint in Bifuzzy Environments

International Journal of Mathematics and Mathematical Sciences, 2014
We study a closed-loop supply chain involving a manufacturing facility and a remanufacturing facility. The manufacturer satisfies stochastic market demand by remanufacturing the used product into “as-new” one and producing new products from raw material ...
Soumita Kundu, Tripti Chakrabarti, Dipak Kumar Jana   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source