Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla +15 more
wiley +1 more source
Reverse exploration: how employees' perception of a high-commitment work system relates to their work-family conflict. [PDF]
Chen S, Ye JH, Pan L, Hu J, Wang L.
europepmc +1 more source
Vacuum‐assisted capillary infiltration delivers perovskite precursors deep into gold nanohole plasmonic hotspots, enabling uniform in situ crystallization of bulk‐like CsPbBr3 within confined cavities. Verified by peel‐off and structural analyses, the hybrid platform shows simulated |E/E₀| ≈2.80 at 800 nm and ∼40‐fold two‐photon absorption‐enhanced ...
Jung‐Jae Do +8 more
wiley +1 more source
When advance directives clash with family consent: designing an operational framework for end-of-life decision-making in China and Korea. [PDF]
Luo S, Cho D, Cho J.
europepmc +1 more source
The performance of Cu‐based photocathodes in photoelectrochemical CO2 reduction is not governed by catalytic sites alone, but by the dynamic journey of photogenerated carriers. This review decodes how carrier generation, recombination, transport, accumulation, extraction, and electrolyte coupling shape catalytic activity, selectivity, and stability ...
Yi‐Cheng Wang +5 more
wiley +1 more source
Trajectories of mental distress and quality of life during Ramadan fasting in young Israeli Muslims are gender-specific. [PDF]
Sindiani M, Korman M.
europepmc +1 more source
Field‐programmed anisotropy imparts material‐level intelligence to soft composites. Magnetic torque dynamics drive magneto‐piezoelectric nanowires from random dispersion into deterministic axial alignment. The resulting hierarchical percolation networks confine electromechanical coupling to specific axes and intrinsically decouple superposed force ...
Yubin Kim +9 more
wiley +1 more source
Barriers and facilitators for implementing WHO's Surgical Safety Checklist in a publicly funded hospital: a qualitative study from a tertiary-level public hospital in Croatia. [PDF]
Krstulović J +6 more
europepmc +1 more source
Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler +14 more
wiley +1 more source
PSgANet: Polar Sequence-Guided Attention Network for Edge-Related Defect Classification in Contact Lenses. [PDF]
Kim SH, Joo I, Yoo KH.
europepmc +1 more source

