Results 41 to 50 of about 449,630 (265)
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Images, 2019 The statement ‘the way up is the way down’ may imply that the spiritual way to perfection lies through humility. It may however also apply to the physical world that is the source of such spiritual metaphors, and within which the actions play out of ...
Paul Coates
doaj +1 more source
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
From Europe with Pride: Heritage, Community and Queer Moves
Open Library of Humanities, 2019 This paper takes Pride (2014) as a focal point for a discussion of a popular European cinema that looks back on key moments in the twentieth-century political past(s) through the re-enactment of queer scenarios of activism and resistance.
Belén Vidal
doaj +2 more sources
Video Essays: Curating and Transforming Film Education through Artistic Research
International Journal of Film and Media Arts, 2020 This article seeks to foster reflection on film pedagogy and research, encouraging academics to engage in artistic research and teaching methods.
Estrella Sendra
doaj +1 more source
, 2016 Jungian Film Studies is a fast-growing academic field. However, Jungian and post-Jungian concepts are still new to most academics and film critics (and are often deliberately neglected by them) who have been using Freud and Lacan as critical tools for decades. Lacanian language in particular has become de riguer – a framework which everyone should know
Bassil-Morozow, Helena, Hockley, Luke
openaire +2 more sources
Arthritis Care &Research, EarlyView.Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli +10 more
wiley +1 more source
Comparing imagery in The Greedy Hippo and Crouching Tiger, Hidden Dragon
Literator, 2012 This article used as point of departure the Ngano song-story entitled The Greedy Hippo as developed by Christiaan van der Westhuizen and based on the Tambani embroidery project. This animated interpretation of The Greedy Hippo is used to further the aims
John R. Botha
doaj +1 more source