Results 1 to 10 of about 3,142,131 (181)

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]

Journal of Virology, 2015
ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Amelia K Pinto, Graham D Williams, José Luiz Proença-módena   +2 more
exaly   +11 more sources

Flow cytometry evaluation of the rhesus monkey cellular immunity following the Zaire ebolavirus (Filoviridae; Ebolavirus: Zaire ebolavirus) experimental infection

Problems of Virology, 2021
Introduction. The outbreaks of the Zaire ebolavirus (ZE) disease (ZED) that have arisen in the last decade determine the need to study the infection pathogenesis, the formation of specific immunity forming as well as the development of effective preventive and therapeutic means.
G. V. Borisevich, S. L. Kirillova, I. V. Shatokhina, V. N. Lebedev, N. V. Shagarova, S. I. Syromyatnikova, A. F. Andrus, E. A. Koval’chuk, V. B. Kirillov, M. L. Bespalov, A. A. Petrov, A. V. Koval’chuk, V. B. Pantyukhov, D. A. Kutayev, S. V. Borisevich, S. L. Kuznetsov   +15 more
openaire   +6 more sources

Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008 [PDF]

PLoS ONE, 2012
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%).
A Grolla, A MacNeil, A Tuffs, AJ Georges, AM Casillas, B Jeffs, B Le Guenno, Benjamin Jeffs, BS Hewlett, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DH Smith, DL Heymann, E Mupere, ED Johnson, EM Leroy, EM Leroy, Esther Sterk, GA Martini, GA Martini, JL Conrad, Joseph Wamala, JS Gear, JS Towner, Julius Lutwama, K Kibadi, K Mupapa, K Mupapa, KJ Davis, M Borchert, M Bray, M Bray, MA Bwaka, Malcolm Gracie Semple, Maria D. Van Kerkhove, Matthias Borchert, ME Miranda, Michel Van Herp, MJ Bonnet, Natasha Howard, NK Jaax, P Formenty, P Formenty, P Francesconi, P Roddy, P Roddy, Paul Roddy, PE Rollin, Pedro Pablo Palma, PH Sureau, R Colebunders, R Ndambi, R Siegert, RC Baron, Robert Colebunders, RT Emond, S Becker, SF Dowell, SP Fisher-Hoch, SR Zaki, TH Roels, U Stroher, Y Kalongi, Zabulon Yoti   +66 more
core   +13 more sources

Climate Change-Driven Heatwaves Pose Lethal Risks to Newborn Forest Bats. [PDF]

Ecol Evol
This is the first recorded case of forest bat mortality in temperate regions caused by heatwaves. The study suggests that forest fragmentation exposes bats to lethal thermal peaks, highlighting a previously overlooked impact of climate change on these mammals and potential interactions with forest fragmentation.
Russo D, Mäenurm A, Cistrone L, Martinoli A, Foiani G, Giongo V, Leopardi S.   +6 more
europepmc   +2 more sources

Marburg Virus Disease: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H.   +4 more
europepmc   +2 more sources

Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]

Molecular Aspects of Medicine, 2008
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins.
Maria Rosaria Capobianchi, Antonino Di Caro, Eloise Mastrangelo   +2 more
exaly   +3 more sources

Evaluation of a Luminex-Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal. [PDF]

Transbound Emerg Dis
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Sankhe S, Diarra M, Barry MA, Faye M, Talla C, Camara D, Mbanne M, Sembene PM, Sall AA, Fall G, Faye O, Loucoubar C, Faye O, Vigan-Womas I, Ricks KM, Radzio-Basu J, Diagne MM.   +16 more
europepmc   +2 more sources

Marburg virus outbreak in Tanzania: A threat to global health security

Public Health Challenges, Volume 2, Issue 4, December 2023., 2023
Abstract The current Marburg virus (MARV) outbreak in Tanzania served as a stark reminder of the ongoing threat posed by emerging infectious diseases and the urgent need for global health security. The Tanzanian Ministry of Health (MoH) officially declared the outbreak on March 21, 2023.
Majani Edward, Godfred Yawson Scott, Withness John, Martha Ernest Rajabu, Elton Mahulu, Shuaibu Saidu Musa, Lucero‐Prisno III Don Eliseo   +6 more
wiley   +1 more source

Autophagy of the ER: the secretome finds the lysosome

The FEBS Journal, Volume 290, Issue 24, Page 5656-5673, December 2023., 2023
The endoplasmic reticulum (ER) and its components can be targeted to the lysosome for degradation during times of stress or protein misfolding. Recent studies have uncovered multiple distinct pathways that deliver the ER along with its contents to the lysosome, which are collectively referred to as ER‐to‐lysosome‐associated degradation (ERLAD). In this
Jeffrey Knupp, Madison L. Pletan, Peter Arvan, Billy Tsai   +3 more
wiley   +1 more source

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source