Results 1 to 10 of about 5,377 (165)

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families [PDF]

Journal of Virology, 2015
ABSTRACT Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5′-triphosphates (5′-ppp) on the genome of viral RNA. However,
Pinto, Amelia K, Williams, Graham D, Szretter, Kristy J, White, James P, Proença-Módena, José Luiz, Liu, Gai, Olejnik, Judith, Brien, James D, Ebihara, Hideki, Mühlberger, Elke, Amarasinghe, Gaya, Diamond, Michael S, Boon, Adrianus C.M.   +12 more
openaire   +8 more sources

Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]

Small Sci
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc   +2 more sources

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High-Throughput Sequencing Data Mining. [PDF]

Adv Sci (Weinh)
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Wang H, Meng Y, Chen X, Cui X, Zuo Q, Han N, Liang X, Shen X, Li C, Li D, Wang F, He L, Chen R, Lu X, You W, Wu A, Chen RA, Chen W, Ding C, Shen Y.   +19 more
europepmc   +2 more sources

Marburg Virus Disease: Pathophysiology, Diagnostic Challenges, and Global Health Preparedness Strategies [PDF]

Annals of Global Health
Background: Marburg virus disease (MVD) is a highly virulent viral hemorrhagic fever with reported case fatality rates of up to 90%. It is part of the same family as the Ebola virus (Filoviridae).
Delfin Lovelina Francis, Saravanan Sampoornam Pape Reddy, Anitha Logaranjani, Subramnayam S Sai Karthikeyan, Manish Rathi   +4 more
doaj   +2 more sources

Marburg Virus Disease: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H.   +4 more
europepmc   +2 more sources

Climate Change-Driven Heatwaves Pose Lethal Risks to Newborn Forest Bats. [PDF]

Ecol Evol
This is the first recorded case of forest bat mortality in temperate regions caused by heatwaves. The study suggests that forest fragmentation exposes bats to lethal thermal peaks, highlighting a previously overlooked impact of climate change on these mammals and potential interactions with forest fragmentation.
Russo D, Mäenurm A, Cistrone L, Martinoli A, Foiani G, Giongo V, Leopardi S.   +6 more
europepmc   +2 more sources

Novel 2-Aryl-1H-Benzimidazole Derivatives and Their Aza-Analogues as Promising Anti-Poxvirus Agents [PDF]

Viruses
Introduction: Despite the impressive progress carried out in the field of biomedical sciences in recent decades, the incidence of emerging and neglected lethal viral infections mainly belonging to the Coronaviridae, Filoviridae, Arenaviridae ...
Valeria Manca, Laura Locci, Roberta Ibba, Laura Sanna, Ilenia Lupinu, Sandra Piras, Gabriele Murineddu, Gabriele Serreli, Roberta Loddo, Rebecca Piras, Luca Virdis, Michela Isola, Vanessa Palmas, Giuseppina Sanna, Antonio Carta   +14 more
doaj   +2 more sources

Understanding Viral Haemorrhagic Fevers: Virus Diversity, Vector Ecology, and Public Health Strategies [PDF]

Pathogens
Viral haemorrhagic fevers encompass a diverse group of severe, often life-threatening illnesses caused by viruses from multiple families, including Arenaviridae, Filoviridae, Flaviviridae, Hantaviridae, Nairoviridae, Peribunyaviridae, and Phenuiviridae ...
Roger Hewson
doaj   +2 more sources

The New Members of Filoviridae Family: Distribution, Natural Reservoirs, Potential Epidemic Danger

Вестник войск РХБ защиты, 2023
The purpose of the work is to analyze the distribution, natural reservoirs and potential epidemic hazard of new members of the Filoviridae family – Bombali viruses (genus Ebolavirus), Lloviu (genus Cuevavirus), Mengla (genus Dianlovirus), Xylang (genus ...
T. E. Sizikova, N. V. Boyarskaya, A. V. Kovalchuk, V. N. Lebedev, S. V. Borisevich   +4 more
doaj   +1 more source

Flow cytometry evaluation of the rhesus monkey cellular immunity following the Zaire ebolavirus (Filoviridae; Ebolavirus: Zaire ebolavirus) experimental infection

Problems of Virology, 2021
Introduction. The outbreaks of the Zaire ebolavirus (ZE) disease (ZED) that have arisen in the last decade determine the need to study the infection pathogenesis, the formation of specific immunity forming as well as the development of effective preventive and therapeutic means.
G. V. Borisevich, S. L. Kirillova, I. V. Shatokhina, V. N. Lebedev, N. V. Shagarova, S. I. Syromyatnikova, A. F. Andrus, E. A. Koval’chuk, V. B. Kirillov, M. L. Bespalov, A. A. Petrov, A. V. Koval’chuk, V. B. Pantyukhov, D. A. Kutayev, S. V. Borisevich, S. L. Kuznetsov   +15 more
openaire   +4 more sources