Results 41 to 50 of about 5,377 (165)

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source

Future Developments and Applications of the Vaccines against Dangerous Viral Infections, RNA-Replicon-Based, Obtained from the Venezuelan Equine Encephalomyelitis Virus

Проблемы особо опасных инфекций, 2014
The members of the Filoviridae (Marburg and Ebola viruses) and Arenaviridae (Lassa, Lujo, Machupo, Junin, Guanarito, Sabia viruses) families are the etiological agents of particularly dangerous viral hemorrhagic fevers.
A. A. Petrov, V. N. Lebedev, T. M. Plekhanova, L. F. Stobva, O. N. Sidorova, E. V. Mel’Nikova, S. V. Borisevich   +6 more
doaj   +1 more source

Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection. [PDF]

PLoS Pathogens, 2012
Marburg virus (family Filoviridae) causes sporadic outbreaks of severe hemorrhagic disease in sub-Saharan Africa. Bats have been implicated as likely natural reservoir hosts based most recently on an investigation of cases among miners infected in 2007 ...
Brian R Amman, Serena A Carroll, Zachary D Reed, Tara K Sealy, Stephen Balinandi, Robert Swanepoel, Alan Kemp, Bobbie Rae Erickson, James A Comer, Shelley Campbell, Deborah L Cannon, Marina L Khristova, Patrick Atimnedi, Christopher D Paddock, Rebekah J Kent Crockett, Timothy D Flietstra, Kelly L Warfield, Robert Unfer, Edward Katongole-Mbidde, Robert Downing, Jordan W Tappero, Sherif R Zaki, Pierre E Rollin, Thomas G Ksiazek, Stuart T Nichol, Jonathan S Towner   +25 more
doaj   +1 more source

Chiroptera as a Potential Reservoir of Dangerous for Humans Viruses in the territory of the Republic of Guinea. Part 1

Проблемы особо опасных инфекций, 2018
Chiroptera is one of the largest in numbers orders of mammals which can take on the role of natural host and vector of various viruses, bacteria, and pathogenic fungi.
A. M. Porshakov, Yu. V. Kononova, V. B. Loktev, M. I. Boiro   +3 more
doaj   +1 more source

In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP‐40

BioMed Research International, Volume 2026, Issue 1, 2026.
The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus.
Boniface Omara, Kenedy Kiyimba, Fatoumata G. Fofana, Oudou Diabaté, Walter Odur, Daudi Jjingo, Jacob Stanley Iramiot, Peace Draleru, Joan Achia, Muhammad Shafiq, Zaheer Ul-Haq, Hedmon Okella, Steven Odongo, Swaran J. S. Flora   +13 more
wiley   +1 more source

Risk Factors for Marburg Hemorrhagic Fever, Democratic Republic of the Congo

Emerging Infectious Diseases, 2003
We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo.
Daniel G. Bausch, Matthias Borchert, Thomas Grein, Cathy Roth, Robert Swanepoel, Modeste L. Libande, Antoine Talarmin, Eric Bertherat, Jean-Jacques Muyembe-Tamfum, Ben Tugume, Robert Colebunders, Kader M. Kondé, Patricia Pirard, Loku L. Olinda, Guénaël R. Rodier, Patricia Campbell, Oyewale Tomori, Thomas G. Ksiazek, Pierre E. Rollin   +18 more
doaj   +1 more source

Factors Associated with Marburg Hemorrhagic Fever: [PDF]

, 2010
Background. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history.
Bengi Moco Henrique, Benjamin Jeffs, Fernando Paixao Damiao Machado, Heinz Feldmann, James E. Strong, Luis Villa, Matthias Borchert, Oscar Bernal, Pascoal Nascimento Folo, Pedro Pablo Palma, Roddy, Paul, Sara L Thomas, Steven M. Jones   +12 more
core   +2 more sources

Filovirus infections: science and innovation

Сибирский научный медицинский журнал
Epidemics of Filovirus Hemorrhagic Fevers demonstrate an increase in incidence, a reduction in the intervals between outbreaks, the emergence of a risk of infection spreading to non-endemic regions in recent years.
L. N. Aftaeva, V. L. Melnikov, A. V. Arekhina   +2 more
doaj   +1 more source

Filoviruses are ancient and integrated into mammalian genomes

BMC Evolutionary Biology, 2010
Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy, Leach Robert W, Taylor Derek J   +2 more
doaj   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source