Results 81 to 90 of about 3,142,131 (181)

Fully human monoclonal antibodies against Ebola virus possess complete protection in a hamster model

Emerging Microbes and Infections
Ebola disease is a lethal viral hemorrhagic fever caused by ebolaviruses within the Filoviridae family with mortality rates of up to 90%. Monoclonal antibody (mAb) based therapies have shown great potential for the treatment of EVD.
Wujian Li, Wanying Yang, Xueqing Liu, Wujie Zhou, Shen Wang, Zhenshan Wang, Yongkun Zhao, N. Feng, Tiecheng Wang, Meng Wu, Liangpeng Ge, X. Xia, Feihu Yan   +12 more
semanticscholar   +1 more source

Filovirus RNA in Fruit Bats, China

Emerging Infectious Diseases, 2015
To the Editor: Filovirus-associated diseases, particularly those caused by Ebola and Marburg viruses, represent major threats to human health worldwide because they have extremely high death rates and antiviral therapies or vaccines against them are not ...
B. He, Yun Feng, Hai-lin Zhang, Lin Xu, Wei-hong Yang, Yuzhen Zhang, Xingyu Li, C. Tu   +7 more
semanticscholar   +1 more source

Epitope-Based Peptide Vaccine against Bombali Ebolavirus Viral Protein 40: An Immunoinformatics Combined with Molecular Docking Studies

bioRxiv, 2020
Background Bombali Ebolavirus is RNA viruses belong to the Filoviridae family. They are causing lethal hemorrhagic fever with high mortality rate. Despite having available molecular knowledge of this virus, no approved vaccine or antiviral drugs have ...
Mujahed I. Mustafa, S. Shantier, Miyssa I. Abdelmageed, Abdelrafie M Makhawi   +3 more
semanticscholar   +1 more source

Viral hemorrhagic fevers: advancing the level of treatment [PDF]

, 2012
The management of viral hemorrhagic fevers (VHFs) has mainly focused on strict infection control measures, while standard clinical interventions that are provided to patients with other life-threatening conditions are rarely offered to patients with VHFs.
Capobianchi, Maria Rosaria, Di Caro, Antonino, Feldmann, Heinz, Ippolito, Giuseppe, Lanini, Simone, Nicastri, Emanuele, Vairo, Francesco   +6 more
core   +3 more sources

Current and future environmental suitability for bats hosting potential zoonotic pathogens in rural Kenya

Ecology and Evolution, Volume 14, Issue 6, June 2024.
Bats are reservoirs for emerging pathogens and may pose significant risks to human health. Understanding spatial overlap between bats and humans across landscapes is a necessary requirement for developing exposure prevention strategies against bat‐borne zoonotic pathogens.
Ruut J. Uusitalo, Reilly T. Jackson, Tamika J. Lunn, Essi M. Korhonen, Joseph G. Ogola, Paul W. Webala, Tarja A. Sironen, Kristian M. Forbes   +7 more
wiley   +1 more source

Comparison of the Efficacy of Different Schemes for Using Recombinant Vector Vaccines against Ebola Fever, Based on Vaccinia Virus, MVA Strain

Problems of Particularly Dangerous Infections
The aim of this review was to investigate the use of the vaccines based on vaccinia virus, MVA stain, and adenovirus vectors for the prevention of Ebola virus disease.
L. F. Stovba, O. V. Chukhralya, D. I. Pavel’ev, N. K. Chernikova, S. Borisevich   +4 more
semanticscholar   +1 more source

Utilizing non‐human primate models to combat recent COVID‐19/SARS‐CoV‐2 and viral infectious disease outbreaks

Journal of Medical Primatology, Volume 53, Issue 1, February 2024.
Abstract In recent times, global viral outbreaks and diseases, such as COVID‐19 (SARS‐CoV‐2), Zika (ZIKV), monkeypox (MPOX), Ebola (EBOV), and Marburg (MARV), have been extensively documented. Swiftly deciphering the mechanisms underlying disease pathogenesis and devising vaccines or therapeutic interventions to curtail these outbreaks stand as ...
Taeho Kwon
wiley   +1 more source

Borna disease virus and its role in the pathology of animals and humans

Regulatory Mechanisms in Biosystems, 2017
Infectious diseases that are caused by numerous pathogenic microorganisms – bacteria, viruses, protozoa or fungi – can be transmitted from patients or carriers to healthy people or animals.
A. O. Mikheev
doaj   +1 more source

Type I interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential

Zoological Research, 2018
Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors (Ifnar–/–) are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to
G. Wong, X. Qiu
semanticscholar   +1 more source

Novel antiviral discoveries for Japanese encephalitis virus infections through reporter virus‐based high‐throughput screening

Journal of Medical Virology, Volume 96, Issue 1, January 2024.
Abstract Japanese encephalitis (JE) caused by JE virus (JEV), remains a global public health concern. Currently, there is no specific antiviral drug approved for the treatment of JE. While vaccines are available for prevention, they may not cover all at‐risk populations. This underscores the urgent need for prophylaxis and potent anti‐JEV drugs.
Chunhong Yin, Peipei Yang, Qingcui Xiao, Peng Sun, Xuekai Zhang, Jiaxuan Zhao, Xue Hu, Chao Shan   +7 more
wiley   +1 more source