Results 231 to 240 of about 11,014 (267)

A highly attenuated pan-filovirus VesiculoVax vaccine rapidly protects nonhuman primates against Marburg virus and three species of Ebolavirus.

Journal of Infectious Diseases, 2023
BACKGROUND The family Filoviridae consists of several virus members known to cause significant mortality and disease in humans. Among these, Ebola virus (EBOV), Marburg virus (MARV), Sudan virus (SUDV), and Bundibugyo virus (BDBV) are considered the ...
Courtney Woolsey, V. Borisevich, K. Agans, Rachel O'Toole, Karla A. Fenton, Mack B. Harrison, A. Prasad, D. Deer, Cheryl S. Gerardi, Nneka Morrison, R. Cross, J. Eldridge, Demetrius Matassov, T. Geisbert   +13 more
semanticscholar   +1 more source

Filovirus Filament Proteins

2018
Filoviruses are highly filamentous enveloped animal viruses that can cause severe haemorrhagic fevers. The filovirus ribonucleoprotein forms a highly organized double-layered helical nucleocapsid (NC) containing five different virally encoded proteins. The inner layer consists of NP, the RNA binding protein, complexed with the monopartite linear genome.
Daniel R, Beniac, Lindsey L, Lamboo, Timothy F, Booth   +2 more
openaire   +2 more sources

Production and Purification of Filovirus Glycoproteins.

Methods in molecular biology
Ebola (EBOV) and Marburg (MARV) viruses cause hemorrhagic fever disease in humans and non-human primates (NHPs) with case-fatality rates as high as 90%. The 2013-2016 Ebola virus disease (EVD) outbreak led to over 28,000 cases and 11,000 deaths and took an enormous toll on the economy of West African nations, in the absence of any vaccine or ...
Madeleine Noonan-Shueh, M. Aman, Shweta Kailasan   +2 more
semanticscholar   +3 more sources

Polymorphism of Filovirus Glycoproteins

2005
Publisher Summary Filoviral glycoproteins are encoded by gene 4 (GP gene) of the nonsegmented negative-strand RNA genome. Nonstructural glycoprotein (sGP) as well as Ebola virus (EBOV) and Marburgvirus (MBGV) GP undergo several posttranslational processing steps giving rise to a whole series of different glycoproteins.
Viktor E, Volchkov, Valentina A, Volchkova, Olga, Dolnik, Heinz, Feldmann, Hans-Dieter, Klenk   +4 more
openaire   +2 more sources

Mechanisms of Filovirus Entry

2017
Filovirus entry into cells is complex, perhaps as complex as any viral entry mechanism identified to date. However, over the past 10 years, the important events required for filoviruses to enter into the endosomal compartment and fuse with vesicular membranes have been elucidated (Fig. 1).
R A, Davey, O, Shtanko, M, Anantpadma, Y, Sakurai, K, Chandran, W, Maury   +5 more
openaire   +2 more sources

[Haemostasis dysregulation in filovirus infections]

Medecine sciences : M/S, 2015
(Uploaded by Plazi for the Bat Literature Project) Filoviruses are responsible for highly lethal infections. Those viruses are found in intertropical areas of Africa and Asia where they circulate in their supposed natural reservoir, fruit bats. During filovirus outbreaks and depending on the strains, various modifications in hemostasis have been ...
Olivier, Reynard, Beatriz, Escudero-Perez, Viktor, Volchkov   +2 more
openaire   +2 more sources

Therapeutics Against Filovirus Infection

2017
Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary goal for infected patients. Years of
John, Connor, Gary, Kobinger, Gene, Olinger   +2 more
openaire   +2 more sources

Filovirus ebola et Marburg

Annales de l'Institut Pasteur / Actualités, 1997
Les filovirus, Marburg et Ebola, sont classes au niveau 4 de securite. Leur haute pathogenicite a ete relevee particulierement chez les sous-types Soudan, Zaire et MBGV. Existent plusieurs modes de transmission, le plus frequent etant le contact physique avec le virus.
Heinz Feldmann, Victor E Volchkov, Klenk Hans-Dieter   +2 more
openaire   +1 more source

Post-exposure therapy of filovirus infections

Trends in Microbiology, 2014
Filovirus infections cause fatal hemorrhagic fever characterized by the initial onset of general symptoms before rapid progression to severe disease; the most virulent species can cause death to susceptible hosts within 10 days after the appearance of symptoms. Before the advent of monoclonal antibody (mAb) therapy, infection of nonhuman primates (NHPs)
Gary, Wong, Xiangguo, Qiu, Gene G, Olinger, Gary P, Kobinger   +3 more
openaire   +2 more sources

Status and challenges of filovirus vaccines

Vaccine, 2007
Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches have met with success in nonhuman ...
Douglas S, Reed, Mansour, Mohamadzadeh
openaire   +2 more sources