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Filovirus Research: How it Began
2017The first reported filovirus outbreak occurred in August 1967, when laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia (now Serbia) became infected with an unknown highly pathogenic agent. The disease was characterized by high fever, malaise, rash, hemorrhagic and tetanic manifestations, and high lethality, amounting to 25%.
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Filovirus clearance in non-human primates
The Lancet, 1992There has been concern in the USA and Europe about filovirus outbreaks in recently imported monkeys, and possible transmission to human beings. Healthy monkeys have been found to have low-titre immunofluorescence antibody (IFA) to Asian filoviruses (Reston and Pennsylvania viruses) as well as to the African filoviruses that caused fulminating human ...
S P, Fisher-Hoch +4 more
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Virologie (Montrouge, France)
Since forty years Marburg and Ebola viruses emerge frequently in Africa and are responsible of viral hemorragic fever outbreaks with high mortality rate. Despite intensive research programs, these viruses remain mysterious: the reservoir is not clearly defined, and the mechanisms leading to their high pathogenicity are poorly understood; a defective or
M-C, Georges-Courbot +2 more
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Since forty years Marburg and Ebola viruses emerge frequently in Africa and are responsible of viral hemorragic fever outbreaks with high mortality rate. Despite intensive research programs, these viruses remain mysterious: the reservoir is not clearly defined, and the mechanisms leading to their high pathogenicity are poorly understood; a defective or
M-C, Georges-Courbot +2 more
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Journal of the American Veterinary Medical Association, 2009
Kelly L, Warfield +2 more
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Kelly L, Warfield +2 more
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Quantification of Filovirus Glycoprotein-Specific Antibodies
2017Serological methods such as the enzyme-linked immunosorbent assay (ELISA) and virus neutralization test are fundamental tools used in diagnosis, seroepidemiological studies of filovirus transmission/prevalence, and the evaluation of vaccine immunogenicity and potential therapeutic antibodies.
Wakako, Furuyama +3 more
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Arenavirus, Filovirus, Bunyavirus.
2020Si tratta di tre famiglie di virus accomunati da caratteristiche strutturali, quali il genoma a RNA racchiuso in un nucleocapside a simmetria elicoidale a sua volta circondato da un pericapside. Causano infezioni gravi nell'uomo e in molti vertebrati, che si manifestano spesso come febbri emorragiche dall'esito letale.
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Synthesis of (1S)-(+)-camphor-10-sulfonamides and evaluation of their anti-filovirus activity
Russian chemical bulletin, 2023A. Sokolova +11 more
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