Results 81 to 90 of about 2,614,519 (287)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

An Optimized Harmonic Current Detection Method Based on ip-iq Method

open access: yesGong-kuang zidonghua, 2010
Principles of traditional ip-iq method using low-pass filter and improved ip-iq method using current average filter were analyzed, and simulation experiment were made.
ZHAO Che
doaj  

FIR to FIR Model Reduction with Linear Group Delay in Passband by SDP Optimization

open access: yesJournal of Electrical and Computer Engineering, 2020
Filter model reduction is an important optimization method in digital signal processing. A method of FIR to FIR model reduction using SDP optimization is proposed in this paper. At first, we use SDP to design an original FIR filter.
Haijiang Hu   +2 more
doaj   +1 more source

Industrial filter bags cleaned by high-frequency vibration: A concept [PDF]

open access: yes, 1973
System holds filter bag around fine-mesh metal screen and vibrates screen at its resonant frequency. This removes deposited byproducts and protects bag fibers from damaging forces.
Kooy, A. V.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Botnet detecting method based on group-signature filter

open access: yesTongxin xuebao, 2010
A botnet detecting method was presented based on group-signature filter,suitable for the traditional signatures matching algorithm.Using multiple member signatures to filter the packets of hosts from Intranet,the proposed method is able to handle the ...
WANG Jin-song1, LIU Fan1, ZHANG Jian3
doaj   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

A new greedy search method for the design of digital IIR filter

open access: yesJournal of King Saud University: Computer and Information Sciences, 2015
A new greedy search method is applied in this paper to design the optimal digital infinite impulse response (IIR) filter. The greedy search method is based on binary successive approximation (BSA) and evolutionary search (ES). The suggested greedy search
Ranjit Kaur   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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