Stoichiometric Binding of Cyclophilin‐A to The HIV‐1 Capsid Modulates Its Mechanoelastic Properties
The HIV‐1 capsid is a protein nanocapsule that must balance rigidity and flexibility to enter the cell nucleus. Atomic force microscopy simulations reveal that binding of the host protein Cyclophilin A tunes this mechanical response: partial coverage preserves deformability, while excessive binding induces brittleness and failure.
Juan S. Rey +2 more
wiley +1 more source
SODNet: a scale-oriented detection network for efficient UAV-based sewage outfall detection. [PDF]
Zeng L, Liu X, Dai B, Wen L, Du Z.
europepmc +1 more source
ABSTRACT Modern engineering faces a ‘complexity crisis’ characterized by interlinked, multidisciplinary ‘wicked problems’, particularly within the defence and aerospace sectors. Although systems thinking is recognized as a critical competency for navigating this environment, empirical quantitative frameworks for its measurement remain limited.
Shimon Fridkin, Sigal Kordova
wiley +1 more source
KAN-Former: a lightweight ECG model for real-time atrial fibrillation detection on wearable devices. [PDF]
Wang K, Wang G, Wu Z.
europepmc +1 more source
Baselining Large Language Model Performance in Systems Engineering Using SysEngBench
ABSTRACT In the rapidly evolving field of artificial intelligence (AI), large language model s (LLMs) have demonstrated impressive capabilities in generating natural language. However, their proficiency in specialized domains, particularly in the field of systems engineering (SE), remains less explored and unquantified.
Ryan Bell +3 more
wiley +1 more source
Essential Oils from Pruning Residues of <i>Lavandula angustifolia</i> Mill. 'Essence Purple' and <i>Helichrysum italicum</i> (Roth) G.Don: Phytotoxic and Ecotoxicological Evaluation. [PDF]
Malaspina P +6 more
europepmc +1 more source
Abstract Brain tumour segmentation employing MRI images is important for disease diagnosis, monitoring, and treatment planning. Till now, many encoder‐decoder architectures have been developed for this purpose, with U‐Net being the most extensively utilised. However, these architectures require a lot of parameters to train and have a semantic gap. Some
Muhammad Zeeshan Aslam +3 more
wiley +1 more source
A Hybrid Federated Learning Framework for Enhancing Privacy and Robustness in Non-Intrusive Load Monitoring. [PDF]
Rong J, Zhou Q, Wu H.
europepmc +1 more source
Boosted unsupervised feature selection for tumor gene expression profiles
Abstract In an unsupervised scenario, it is challenging but essential to eliminate noise and redundant features for tumour gene expression profiles. However, the current unsupervised feature selection methods treat all samples equally, which tend to learn discriminative features from simple samples.
Yifan Shi +5 more
wiley +1 more source
HAPQ: A Hardware-Aware Pruning and Quantization Pipeline for Event-Based SNN Detection. [PDF]
Li Z, Wu J.
europepmc +1 more source

