Results 171 to 180 of about 8,246 (227)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Network Topology and Undominated Assembly Processes Govern Soil Nematode Community Responses to Forest Type. [PDF]

Microorganisms
Yang B, Zhang Z, Liu Y, Wang Z, Sheng Y, Yang Z.   +5 more
europepmc   +1 more source

Innovation and Growth Investment Through Capital Expenditure as a Channel and Boundary Condition Between Financial Performance and Corporate Reputation

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the role of capital expenditure in the relationship between financial performance and corporate reputation. Using moderation and mediation analyses based on multiple regressions with bootstrapping, we examined data from 121 airlines from 46 countries during 2007–2023.
Larissa M. Batrancea, Andreas‐Daniel Cocis, Ioan Dan Morar   +2 more
wiley   +1 more source

Uncertainty-Aware Remaining Useful Life Prediction via Synergizing TCN-Transformer Networks and Fractional Brownian Motion. [PDF]

Entropy (Basel)
Geng Y, Yu T, Liu Y, Zhao J.
europepmc   +1 more source

Symbolic Versus Substantive ESG Practices: A Systematic Review and Integrative Framework

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT ESG reporting is widespread, but symbolic commitments do not always reflect substantive practices. This study conducts a systematic literature review of 62 empirical articles published between 2021 and 2025 to synthesize the main determinants and consequences of this disclosure–performance misalignment in ESG reporting (commonly referred to as
Cristina Alexandrina Ştefănescu, Andra Larisa Suciu   +1 more
wiley   +1 more source

A Framework for Integrating Large Language Models into Memetic Algorithms. [PDF]

Biomimetics (Basel)
Sakharov M.
europepmc   +1 more source

DinoFlow: Self‐supervised pretraining in flow cytometry enables accurate detection of common hematopathological disorders

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Flow cytometry is an essential component of routine hematological lab testing. Many computational methods have been proposed for the analysis of flow cytometry data, but most have focused on supervised learning for just one or a few specific disorders.
Brendan O'Fallon, Muir Morrison, Mattia Medina Grespan, Nicholas C. Spies, David P. Ng   +4 more
wiley   +1 more source

Bayesian attenuation of offset analgesia filters out random disturbances in noxious stimuli. [PDF]

Pain Rep
Ishikawa R, Osumi M, Izawa J.
europepmc   +1 more source

Acoustic‐driven surface cleaning with millimeter‐sized bubbles at translational resonance

Droplet, EarlyView.
Time‐lapse visualization comparing bubble trajectories. The top panel (0 Hz) shows a bubble's linear path under no acoustic forcing, while the bottom panel (50 Hz) demonstrates the oscillatory motion induced by acoustic waves at a resonance mode. This mechanism holds promising potential for applications such as surface cleaning.
Yan Jun Lin, Zhengyang Liu, Sunghwan Jung   +2 more
wiley   +1 more source

Dynamic guidance control for UAV landing on autonomous surface vessel. [PDF]

Sci Prog
Lin CY, Tseng YC, Yao WS.
europepmc   +1 more source