Results 151 to 160 of about 1,984,766 (287)

The long-term outcome of trabeculotomy: comparison with filtering surgery in Japan. [PDF]

open access: yesBMC Ophthalmol, 2019
Bao W   +4 more
europepmc   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong   +20 more
wiley   +1 more source

Clinical Impact of the Use of Ologen in Filtering Surgery Performed in Uncontrolled Glaucoma. [PDF]

open access: yesJ Clin Med
Navero-Rodríguez JM   +4 more
europepmc   +1 more source

The Effect of Multivesicular Liposome - encapsulated Cytarabine on Wound Healing of the Glaucoma Filtering Surgery

open access: yes, 1994
In this study, multivesicular liposome-encapsulated cytarabine was injected subconjunctivally to observe the effects on wound healing, its complications, and the possibility of this method for decreasing frequency of injections.
성공제
core  

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang   +8 more
wiley   +1 more source

Evaluating the efficacy and safety of polyglycolic acid-loading mitomycin nanoparticles in inhibiting the scar proliferation after glaucoma filtering surgery. [PDF]

open access: yesAnn Med
Li T   +19 more
europepmc   +1 more source

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