Results 71 to 80 of about 144,653 (287)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Ptosis after glaucoma surgery

Clinical Ophthalmology, 2017
Abraham J Park,1 Babak Eliassi-Rad,2 Manishi A Desai2 1Moyes Eye Center, Department of Ophthalmology, 2Boston Medical Center, Department of Ophthalmology, Boston, MA, USA Purpose: Evaluate factors contributing to ptosis after glaucoma surgery. Methods:
Park AJ, Eliassi-Rad B, Desai MA
doaj  

Short-Term Outcomes of a Modified Safer Surgery Trabeculectomy Technique

Journal of Current Ophthalmology
Purpose To determine the short-term outcomes of a modified Moorfields Safer Surgery System technique of trabeculectomy. Methods This is a prospective interventional study.
Prakriti Yagnam Konuganti, Muralidhar Rajamani, Craig John Chaya, Chitra Ramamurthy   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

XEN Gel Stent Failure Due to Luminal Obstruction

Journal of Ophthalmic & Vision Research
Purpose: To discuss four cases of post-operative XEN gel stent luminal obstruction in patients with primary open angle glaucoma. Case Report: Four eyes in three patients with primary open angle glaucoma who received XEN stent implantation were found to ...
Dilru C. Amarasekera, Vikram A. Shankar, Reza Razeghinejad   +2 more
doaj   +1 more source

Recursive Least Squares Filtering Algorithms for On-Line Viscoelastic Characterization of Biosamples [PDF]

, 2018
The mechanical characterization of biological samples is a fundamental issue in biology and related fields, such as tissue and cell mechanics, regenerative medicine and diagnosis of diseases.
Aceto, Maria, Di Giamberardino, Paolo, Giannini, Oliviero, Verotti, Matteo   +3 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

4-YEAR FOLLOW UP OF PATIENTS AFTER GONIOTREPANATION

Zdravniški Vestnik, 2002
Background. To present the success of goniotrepanation in patients with glaucoma 4 years after surgery.Methods. We performed follow-up of 32 patients (50 eyes), who had undergone Fronimopoulus goniotrepanation without use of antimetabolites in our ...
Mojca Hudovernik, Dušica Pahor
doaj  

Case Base Mining for Adaptation Knowledge Acquisition [PDF]

, 2007
In case-based reasoning, the adaptation of a source case in order to solve the target problem is at the same time crucial and difficult to implement.
Badra, Fadi, D'Aquin, Mathieu, Lafrogne, Sandrine, Lieber, Jean, Napoli, Amedeo, Szathmary, Laszlo   +5 more
core   +5 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source