Results 51 to 60 of about 5,776,143 (257)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini +8 morewiley +1 more sourceN-acetylcysteine in the prevention of radiocontrast-induced nephropathy: clinical trials and end points [PDF]
, 2004 N-acetylcysteine (NAC) has been suggested to prevent radiocontrast-induced nephropathy (RCIN) in patients with a reduced renal function. However, clinical studies have not been demonstrating this effect consistently.Hoffmann, Ute, Banas, B., Hoffmann, U., Banas, Bernhard, Fischereder, Michael, Kramer, B. K., Fischereder, M., Krämer, Bernhard K. +7 morecore +1 more sourceGenome-wide association and functional follow-up reveals new loci for kidney function [PDF]
, 2012 Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new Döring, Angela, Atkinson, Elizabeth J, Gary C Curhan, Wichmann HE, Thun, G.-A., Trompet, S., Heid, I. M., Goessling Wolfram, Kroemer H.K., Boerwinkle, E., Kähönen M., Wilson J.F., Franke A., Biffar Reiner, Palmer, C., Zemunik T, Toshiko Tanaka, Rettig Rainer, Rao, Madhumathi, Toniolo, D. (Daniela), Smith, AV, Liu C.-T., Harshal Deshmukh, Curhan, G. C., Foster, Meredith C, Taliun, D, Heid Iris M., Gao, XY, Ridker P., Glazer, N., Fox Caroline S., Liu, Ching-Ti, Struchalin, M.V. (Maksim), Trompet, S. (Stella), O´Connell, J.R., Böger C.A., Chu, A.Y., de Andrade M, Smith AV, Fuchsberger Christian, Krämer, B.K., Hwang, S. J., Atkinson, Elizabeth J., Igl, W., Harris, T.B. (Tamara), Jingzhong Ding, Turner ST, Vollenweider Peter, Voelker, Uwe, Adrienne Tin (160761), Toniolo, D, J. Wouter Jukema (127361), Johnson, A.D. (Andrew), Vincent Chouraki, Uitterlinden A.G., Gorski, M. (Mathias), Adam M, Andrews JS, Rivadeneira, F, Turner, S. T., Wheeler, H.E., Gyllensten, Ulf,, Turner, ST, Rao M, Henry Völzke (64286), Meredith C. Foster (165430), Tin, A., Florian Kronenberg (87557), Andrews, J.S. (Jeanette), Nikopensius, Tiit, Shuldiner AR, Rudan, I. (Igor), Jie Jin Wang (103779), Borecki, I, Freedman, BI, Portas L, Ulivi, S, Nauck, Matthias, et al., Rao Madhumathi, Smith, A.V. (Albert Vernon), Stumvoll Michael, Ketkar S, Imboden, Medea, Peter P. Pramstaller (150111), Trompet S., Gudny Eiriksdottir (8872), Doney, A., Hastie N., Karlhans Endlich, Illig T, Vitart, Veronique, Homuth, G. (Georg), Rao M., Johansson, Åsa,, Kolcic, I. (Ivana), O'Seaghdha, Conall, Kähönen, M., Ketkar, S, Cavalieri, M., Probst-Hensch, NM, Wright, A.F., Gao, X., Deshmukh H, Minelli, Cosetta, Gasparini P., Chu, AY, Ciullo, M., Conall M O'Seaghdha, Ulf Gyllensten, Li, M. (Man), Probst-Hensch, Nicole M., Paulweber, B, Wild, S.H. (Sarah), Robino, A, Atkinson EJ, Rettig R, Buckley, B.M., Dehghan A, Johansson, Å, Illig, T., Yang, Q., Franke, Andre, Wang, J.J. (Jie Jin), Adam M., Biffar R., Colhoun, H., Cornelis MC, Curhan GC, Kolcic Ivana, Thun, G.A., Borecki I, Ding, JZ (Jing Zhong), Tönjes A., Tönjes, A. (Anke), Ding Jingzhong, Iris M Heid, Völzke, H, Kim, SK, Lohman K, Kroemer, H. K., Thun, G. A., Liu, CT, Hofman A, Köttgen, Anna, Qiong Yang, Ferrucci Luigi, Adam Martin, Boban, M., Wright, AF, Aulchenko, Y.S., Mariza de Andrade (31845), Holliday, E.G., Zaboli, G, Ding, Jingzhong, Albert V Smith, Bernhard Paulweber, Probst-Hensch Nicole M., Florian Ernst, Nick Hastie, Luigi Ferrucci (150038), Endlich Karlhans, Stumvoll, M. (Michael), Nicole M Probst-Hensch, Polasek, Ozren, Matthias Nauck, Stuart K. Kim (112150), De Andrade, M, Andrews, Jeanette S., van Duijn, Cornelia M., Anna Köttgen, Ciullo, M, Kao, WHL, Karlhans Endlich (112716), Garnaas Maija, Trompet, Stella, Palmer, Colin; id_orcid, Murgia, Federico, Struchalin, M., Gibson, G., Thor Aspelund, Ozren Polasek (3965693), Chen, M.H., Ching-Ti Liu, Pramstaller, PP, Hwang Shih-Jen, Rettig R., Vollenweider, P, Wilmar Igl, Oostra Ben A., Kovacs P, Afshin Parsa (175121), Coresh, J., Kutalik, Z. (Zoltán), Esko, T. (Tõnu), Fuchsberger, C., Pirastu, M, Cornelis, Marilyn C, Pistis, G, Chouraki, V. (Vincent), Tanaka, T, Haun M., Struchalin Maksim, Thun GA, Mägi, R., Mitchell, Braxton D., Demirkan, A, Köttgen, A., Colhoun H, Deshmukh, H., Liu Y., Launer, L. J., Garnaas M., Heid, I.M. (Iris), Andrade, M. de, Franke, A., Biffar, R., Chasman, D.I. (Daniel), Gyllensten Ulf, Campbell, Harry, Teumer, A. (Alexander), Goessling, W, Man Li (81239), Colin Palmer (165015), Liu, C. T., Ellinghaus, D., Wichmann H.-E., Wang JJ, Feitosa, M.F. (Mary Furlan), Jacqueline C. M. Witteman (175109), Bochud, M., Andrews, J. S., Bergmann, S, Tin Adrienne, O'Seaghdha C.M., Parsa, A., Goessling W, Döring Angela, Li G., Uitterlinden Andre G., Thun G.-A., Hu, Frank B., Portas, Laura, Gorski M, Chasman, DI, Georg Homuth (110202), Kardia, S.L.R., Kronenberg F, Holliday, E. G., Pistis, G. (Giorgio), Fox, C.S., Vilmundur Gudnason, Mitchell, Paul, Freedman Barry I., Doering, Angela, Ruggiero D., Wild S.H., Li, M., Ivana Kolcic, Chu, Audrey Yu-lei, Wilson, J.F., Imboden M, Goessling, W. (Wolfram), Raitakari, O., van Duijn CM, Wolfgang Koenig, Marie Metzger (156894), Chen M.-H., Launer Lenore J., Li M., Ding, J.Z., Schmidt, H., Mladen Boban, Ghazal Zaboli (174959), Ernst, F, Jacobs, Gunnar, Wichmann, HE, Isaacs, A., Kardia, Sharon L. R., Stracke, Sylvia, Trompet Stella, Stuart K Kim, Boban, Mladen, Koenig, W. (Wolfgang), Hwang, S.J., Wilson, James F; id_orcid, Nicole Glazer, Kim S.K., Feitosa M., Kovacs, P, Bergmann, S., Völker, U., Jukema J. Wouter, Rettig, R. (Rainer), Teumer, Alexander, Wright Alan F., Demirkan, A. (Ayşe), Ciullo Marina, Toshiko Tanaka (174638), Illig, T, Cavalieri M., Ming-Huei Chen, Bochud M., Aulchenko, Yurii S., Ute Nöthlings (140098), Toniolo Daniela, Nauck Matthias, Prokopenko, I, Giorgio Pistis, Böger CA, Struchalin, M, Schmidt, R. (Reinhold), Gian-Andri Thun, Kao WH, Hayward C, Colhoun Helen, Paul Mitchell (103717), Guo Li (174860), Cinzia Sala (74631), Siscovick D.S., Kardia, S.L., Gasparini, Paolo, Gudnason Vilmundur, Fox, Caroline, Giulianini F., Kovacs, Peter, Laura Portas (175069), Jacobs G, Parsa, A. (Afshin), Chen Ming-Huei, Reedik Mägi, Hayward, Caroline, Hofman, A. (Albert), Lehtimäki T, Viikari Jorma, Abbas Dehghan (174878), Albert Hofman, Igl, Wilmar, Daniel Taliun, Wild, S. H., Aspelund Thor, Ford, I., Nauck M., CARDIoGRAM Consortium, Kroemer, H.K., Hu Frank B., Heid I.M., Wheeler H.E., O'Seaghdha, Conall M, Coresh, J, Nick Hastie (175020), Tin, Adrienne, Mitchell, P, Schmidt, R., Helena Schmidt (174915), Aspelund, T, Deshmukh, Harshal, Elizabeth G Holliday, Wheeler HE, Oostra, B.A., Pirastu Mario, Stumvoll M, Turner, S.T., Völker U., Glazer N., Mitchell, P., Atkinson E.J., Chu A.Y., Paul Mitchell, Peter Kovacs (103720), Martin Adam (175082), Wilson, JF, Yang Q, Rossella Sorice, Alan R. Shuldiner (110828), Böger, Casten A, Tiit Nikopensius, Ernst Florian, Portas, L., Sorice, R, Taliun Daniel, Nikopensius T., Jukema J.W., Li, G., Metzger M., Cavalieri, M. (Margherita), Cinzia Sala, Zaboli G, Glazer Nicole, Pistis Giorgio, Kao, W. H. Linda, Wilson, J.F. (James), Murgia, F, Foster, M.C., Pattaro C., Wright A.F., Kardia, S.L.R. (Sharon), Andre Franke, Ellinghaus D, Braxton D Mitchell, Yurii S. Aulchenko (148330), Mitchell B.D., Peter Kovacs, Kaehoenen, Mika, Stracke S., Li, G (Guo), Rivadeneira Ramirez, F. (Fernando), Mario Pirastu (175088), Olden M, Ford, I. (Ian), Oostra B.A., Campbell, H. (Harry), Holliday EG, Wichmann, H.-E., Ciullo M, Lenore J. Launer (110269), Hu, F.B., Kao, W.H.L., Buckley, BM, WTCCC2, Gao, X, Thomas Illig (44906), Sala, C, Colhoun, Helen, Van Duijn, CM, Demirkan, A., Bochud, Murielle, Yang Q., Aspelund T, Eiriksdottir, G, Gasparini, P., Nikopensius Tiit, Wang, JJ, Uitterlinden, AG, Illig, T. (Thomas), Homuth G., Tamara B Harris, Deshmukh Harshal, Vitart Veronique, Madhumathi Rao, Chen MH, Haun, Margot, Hundertmark C., Carsten A Böger, Giulianini, F., Chu, Audrey Y, Aspelund, T. (Thor), Andrews Jeanette S., Madhumathi Rao (174925), Margherita Cavalieri (174919), Kronenberg F., Nauck, M., Cosetta Minelli, Campbell, Harry; id_orcid, Metzger Marie, Ferrucci, L. (Luigi), Sharon L R Kardia, Kolcic, I., Wheeler, HE, Kollerits, Barbara, Angela Döring (64291), de Andrade Mariza, Florian Ernst (174614), David Ellinghaus (87596), Liu CT, Ford, Ian, Conall M. O'Seaghdha (174855), Ford I., Colhoun H., Daniela Toniolo, Imboden M., Zemunik T., Shuldiner, A.R., Ingrid Borecki (175089), Kutalik Zoltan, Boerwinkle E., Paulweber Bernhard, Liu Y, Pattaro C, Wild Sarah H., Kovacs Peter, Province, M., Sorice R., Prokopenko, Inga, Hwang S.-J., Bergmann, Sven, Launer, Lenore J., Fox, C. S., Bergmann, S.M. (Sven), Wichmann, H. E., Giulianini Franco, Garnaas, M., Jacobs G., Imboden, M. (Medea), Franke Andre, Parsa A, Magi, Reedik, Liu, C.-T., Esko, T, David S. Siscovick (174822), Gierman Hinco J., David Ellinghaus, Brendan M. Buckley (175076), Buckley Brendan M., Lohman, K, Nikopensius, T, Aulchenko, Y. S., Boban, M, Maija Garnaas, Gunnar Jacobs (174977), Andre G. Uitterlinden (89938), Minelli C., Jukema, J.W., Schmidt, Helena, Ferrucci L., Luigi Ferrucci, Koenig, W, Stumvoll M., Probst-Hensch, N.M., Gyllensten U., Homuth, G., Mika Kähönen, H-Erich Wichmann, Meredith C Foster, Uitterlinden, A. G., Jacobs, Gunar, Andres Metspalu (61760), Sorice, Rossella, Fuchsberger, Christian, Goessling, Wolfram, Curhan Gary C., Coresh J, Haun M, Paolo Gasparini (139832), Laura Portas, Esko Tõnu, Rainer Rettig (112747), Endlich K., Freedman, B.I., Haun, M. (Margot), Polasek, O., Chu AY, Hinco J Gierman, Ayse Demirkan (174933), Endlich, Karlhans, Homuth, Georg, Harris, TB, Nöthlings Ute, Hundertmark, C., Zemunik, T. (Tatijana), Sorice, R., Franke, A. (Andre), O'Connell, J.R., Kollerits B, Jingzhong Ding (165392), Province Michael, Elizabeth J. Atkinson (174866), Li, Guo, Oostra, B.A. (Ben), Gao X, Kao W.H.L., Ruggiero Daniela, Parsa Afshin, Yongmei Liu, Antonietta Robino (149863), Vitart, V, Mitchell, B.D. (Braxton), Fuchsberger C, Raitakari O., Hayward, C, Pramstaller PP, Deshmukh H., Rossella Sorice (140754), Vilmundur Gudnason (8873), Borecki, I.B. (Ingrid), Gyllensten, U. (Ulf), Gorski, M, Eiriksdottir Gudny, Böger, CA, Audrey Y. Chu (174895), W. H. Linda Kao (160779), Helena Schmidt, Probst Hensch NM, Ding J., Igor Rudan, Wichmann, H. -Erich, Siscovick, D.S. (David), Paulweber, Bernhard, O'Seaghdha, C. M., Ferrucci, L., Foster Meredith C., Oostra, B. A., Palmer C., O'Seaghdha, C.M., Marie Metzger, Henry Völzke, Antonietta Robino, Esko T, Alex Doney (175054), Isaacs, A, Tönjes, A, Gudnason V., Lehtimäki, T, Helen Colhoun, Cornelis, Marilyn, Giulianini F, Thun Gian-Andri, Campbell, H, Claudia Hundertmark (174852), Hofman, Bert, Wright, A. F., Kutalik Z., Toniolo, D., Hwang SJ, Eiriksdottir G, Kolcic, I, Ferrucci, Luigi, Teumer A., Johnson A.D., Bernhard K Krämer, Olden, M., Olden, M, Hundertmark Claudia, Michael Stumvoll, Mägi R., Jorma Viikari, Witteman JC, Ulivi, Sheila, Kim, Stuart K., Heid, IM, Fuchsberger, C, Wichmann, H.-Erich, Heyo K Kroemer, Uitterlinden, André, Anke Tönjes, Krämer, Bernhard K., Tin A, Hundertmark, Claudia, Siscovick, DS, Struchalin, Maksim, Gao, X.Y., Kollerits, B. (Barbara), Holliday, EG, Gian-Andri Thun (142891), Sven Bergmann, Albert V. Smith (103644), Johansson Åsa, Stella Trompet, Murgia, F., Chen, M. H., Franco Giulianini, Lehtimaeki, Terho, Coresh, J. (Josef), Nothlings, Ute, Olden, M. (Matthias), Michael Province (175044), Demirkan Ayse, Wild, S.H., de Andrade, M., James F Wilson, Eiriksdottir, G., Eric Boerwinkle (36288), Federico Murgia (174898), Bernhard Paulweber (102633), Robino Antonietta, Johnson, AD, Alan F Wright, Metspalu A, Mitchell Paul, Catherine Helmer (175026), Wheeler, Heather E., Medea Imboden (110145), Gorski, M., Probst-Hensch, N. M., Caroline Hayward, Krämer B.K., Harris, Tamara B., Chouraki, Vincent, Trompet S, Giulianini, Franco, Harry Campbell, Ivana Kolcic (3212697), Frank B. Hu (127167), Launer, LJ (Lenore), Demirkan, Ayse, Schmidt, R, Uitterlinden, André; id_orcid, Schmidt, H, Ben A Oostra, Province, Michael, Veronique Vitart, Rivadeneira, F., Helmer, C, Hayward Caroline, Reiner Biffar (135695), Viikari, J, Rudan, Igor, Anna Köttgen (3111024), Mitchell Braxton D., Völzke H, Koenig Wolfgang, Martin Adam, Veronique Vitart (149854), Sylvia Stracke (175001), Turner S.T., Guo Li, Wilson, J. F., Dehghan, A. (Abbas), Smith, A. V., Völzke, H., Freedman, Barry I., Dehghan A., Igl W., Harris Tamara B., Köttgen A., Rettig, R., Chouraki V, Province, M, Ellinghaus David, Tin, A, Palmer, Colin, Jacobs Gunnar, Holliday, E.G. (Elizabeth), Rainer Rettig, Uitterlinden, A.G., Teumer A, Sarah H Wild, Pramstaller P.P., Biffar, R. (Reiner), Ford I, Wheeler, H. E., Nauck, M. (Matthias), Ridker, P.M. (Paul), Polasek Ozren, Adam, M., Kutalik, Z., Ferrucci L, Margherita Cavalieri, Oostra BA, Cornelis, M. (Marilyn), Alan F. Wright (150085), Kolcic, Ivana, Olden Matthias, Goessling, W., Tönjes A, Chouraki Vincent, Raitakari, O. (Olli), Hofman, A, Cavalieri, Margherita, Doney A, Hwang, S.-J., Angela Döring, Rudan, I, Curhan, G.C., Metspalu A., Launer, LJ, Vitart, V., Andrew D Johnson, Thun, GA, Thor Aspelund (103668), Döring, A, Isaacs A, Witteman, J.C.M. (Jacqueline), Christian Fuchsberger, Chen, M-H. (Ming-Huei), O'Connell, Jeffrey R., Hayward, Caroline; id_orcid, Uwe Völker, Vollenweider, P. (Peter), Pattaro, C. (Cristian), Polasek, O, Launer L.J., Michael Stumvoll (103716), Gierman, H.J., Palmer C, Johnson Andrew D., Chouraki, V., Krämer, BK, Ding, J., Caroline Hayward (149856), Paulweber B., Zaboli, Ghazal, Hastie Nick, Rivadeneira F., Mitchell P., Pirastu, Mario, Wang, Jie Jin, Gorski Mathias, Lehtimäki Terho, Nöthlings, U, Igor Rudan (150101), Borecki Ingrid, Shamika Ketkar, Curhan G.C., Illig T., Nicole Glazer (113632), Rao, M, Uitterlinden, Andre G., Rettig, Rainer, Schmidt R., Reinhold Schmidt, Ketkar, Shamika, Heid IM, Stella Trompet (174901), Zoltan Kutalik, Wheeler Heather E., Kronenberg, F. (Florian), Kutalik, Zoltan, Johansson, Asa, Johansson Å, Gasparini, P, Kronenberg, Florian, Elizabeth J Atkinson, Hofman, A., Sarah H. Wild (130180), Smith, Albert V, Schmidt, Reinhold, Palmer, C.N.A. (Colin), Vollenweider P., Doney Alex, Wilson JF, Minelli Cosetta, Ulivi, S. (Shelia), Prokopenko I, Gorski, Mathias, Struchalin M, Ridker, P, Hu FB, Kollerits, B, Heather E Wheeler, Toniolo D., Hofman Albert, Sala, Cinzia, Lehtimäki, Terho, Andres Metspalu, Abbas Dehghan, Kurt Lohman, O'Seaghdha, CM, Mladen Boban (149857), Kähönen Mika, Krämer Bernhard K., Gyllensten, U., Pramstaller, P.P. (Peter Paul), Qiong Yang (28822), Kähönen, M, O'Seaghdha, Conall M., Kurt Lohman (110218), Biffar, R, Thomas Illig, Ghazal Zaboli, Cornelis, Marilyn C., Launer, L.J., Homuth G, Chasman, Daniel I., Sala C, Mägi Reedik, Fernando Rivadeneira, Launer LJ, Zaboli G., de Andrade, Mariza, Shih-Jen Hwang, Jeanette S. Andrews (174941), Marina Ciullo (140763), Ulivi Sheila, Tamara B. Harris (110195), Atkinson Elizabeth J., Holliday, Elizabeth G., Daniel I Chasman, Yang, Qiong, Braxton D. Mitchell (110791), Kollerits Barbara, Gierman, Hinco J, Kovacs, P., Gierman HJ, Atkinson, E. J., Kardia Sharon L. R., Ciullo M., Isaacs, Aaron; id_orcid, Andrews J.S., Duijn, C.M. van, Lohman Kurt, Shih-Jen Hwang (79945), Harris TB, Zemunik Tatijana, Franke, A, Bergmann S, Paul Ridker, Ruggiero, D, Gierman, HJ, Gyllensten, Ulf, Helmer C, Nikopensius T, Franke A, Bochud M, Fuchsberger C., Dehghan, Abbas, Atkinson, EJ, Cristian Pattaro, Minelli C, Caroline S Fox, Schmidt Helena, Pramstaller, P. P., Taliun D., O'Connell, J. R., Demirkan A., van Duijn C.M., James F. Wilson (150146), Böger, C. A., Bergmann S., Palmer Colin, Johnson AD, Wright, A.F. (Alan), Stephen T. Turner (103474), Ching-Ti Liu (100170), Mary Feitosa (165417), Vitart, V. (Veronique), Pistis G., Ridker Paul, Margot Haun, H.-Erich Wichmann (72009), Ian Ford (30666), Harry Campbell (30339), Boban Mladen, Freedman BI, Pirastu M., Ulivi, S., Raitakari, Olli, Krämer BK, Rudan Igor, Rudan, I., Jukema, J. W., Ulivi S., Franco Giulianini (175060), Wilson, James F., Sala, C. (Cinzia), Chu, Audrey Y., Hinco J. Gierman (174862), Ulf Gyllensten (13773), Siscovick, D. S., Stracke, S., Doney, A, Metzger M, Li, Man, Wang, J. J., Illig, Thomas, Tõnu Esko (102379), Döring, A. (Angela), Hu, Frank, Völker Uwe, Mary Feitosa, Igl, W, Chen, M.-H., Koenig W, Adam, M, Vitart V, O'Connell, Jeffrey R, Ketkar S., Imboden Medea, Cosetta Minelli (38846), Johnson, Andrew D., Reiner Biffar, Völzke H., Matthias Olden, Mariza de Andrade, Aulchenko, Y.S. (Yurii), Hwang, Shih-Jen, Jukema JW, Portas L., Hwang, SJ, Polasek, O. (Ozren), Lohman, Kurt, Ford Ian, Wellcome Trust Case Control Consortium 2, Gyllensten, U, Vitart V., Harshal Deshmukh (174893), Freedman B.I., Caroline S. Fox (110474), Yang, Q. (Qiong Fang), Alexander Teumer (112757), Holliday, Elizabeth G, Kao W. H. Linda, Marilyn C. Cornelis (174871), Boger, C.A., Kroemer, H.K. (Heyo), Parsa, Afshin, Kovacs P., Tõnu Esko, Liu Ching-Ti, Dehghan Abbas, Buckley B.M., Jukema, J. Wouter, Haun, M, Anke Tönjes (103703), Johnson, A.D., Afshin Parsa, Ernst F., Vollenweider, P., Völker U, Jeffrey R. O'Connell (170220) +999 morecore +2 more sourcesPartial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig +10 morewiley +1 more source
