Results 51 to 60 of about 4,363,357 (287)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Multipoint initial-final value problems for dynamical Sobolev-type equations in the space of noises

Electronic Journal of Differential Equations, 2018
We prove the existence of a unique solution for a linear stochastic Sobolev-type equation with a relatively p-bounded operator and a multipoint initial-final condition, in the space of ``noises''.
Angelo Favini, Sophiya A. Zagrebina, Georgy A. Sviridyuk   +2 more
doaj  

Proposed shunt rounding technique for large-scale security constrained loss minimization [PDF]

, 2010
The official published version can be obtained from the link below - Copyright @ 2010 IEEE.Optimal reactive power flow applications often model large numbers of discrete shunt devices as continuous variables, which are rounded to their nearest discrete ...
Hurlock, P, Irving, MR, MacFie, PJ, Taylor, GA, Wan, H   +4 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Distress Signals: Historical Waypoints in Northwest Atlantic Fisheries Since 1850

Oceanography, 2018
By inviting a historian to deliver the 2018 Roger Revelle Lecture, the Ocean Studies Board signals the value of fruitful engagement between the sciences and the humanities. Their decision honors Roger Revelle’s legacy.
W. Jeffrey Bolster
doaj   +1 more source

PENERAPAN METODE FAILURE MODE AND EFFECT ANALYSIS (FMEA) DALAM MENGIDENTIFIKASI MASALAH KERUSAKAN PRODUK PAKAN AYAM PADA PT. JAPFA COMFEED INDONESIA, TBK UNIT LAMPUNG

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2019
PT. Japfa Comfeed Indonesia, Tbk Unit Lampung is a company engaged in the field of animal feed with two types of products, namely pellet and crumble.
Marcelly Widya Wardana, Sulastri, Siti Hasanah   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

On a final value problem for a biparabolic equation with statistical discrete data

Applicable Analysis, 2020
This article is devoted to the study of final value problems for biparabolic equation with discrete data in two cases as the linear source and the nonlinear source, respectively. In each of the cases, we show the instability of the solutions and then establish approximate solutions by applying some regularization methods.
Nguyen Huy Tuan, Tran Ngoc Thach, H. Vu, Nguyen Huu Can   +3 more
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Enhanced Qualitative Understanding of Solutions to Fractional Boundary Value Problems via Alternative Fixed-Point Methods

Axioms
In this work, we study Caputo fractional boundary value problems and contribute to the theory of fractional differential equations by improving the results of Ferreira.
Saleh S. Almuthaybiri, Abdelhamid Zaidi, Christopher C. Tisdell   +2 more
doaj   +1 more source