Results 51 to 60 of about 99,615 (311)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dynamics of a stochastic eutrophication-chemostat model with impulsive dredging and pulse inputting on environmental toxicant

Advances in Difference Equations, 2020
In this paper, we present a stochastic eutrophication-chemostat model with impulsive dredging and pulse inputting on environmental toxicant. The sufficient condition for the extinction of microorganisms is obtained.
Jianjun Jiao, Qiuhua Li
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Other title: National Provider Identifier Project Update [PDF]

, 2006
"June 12, 2006."; The Division of Health Policy and Finance was transferred to the Kansas Health Policy Authority on July 1, 2006.; Testimony before the Kansas Legislature, Joint Committee on Information Technology, by Christiane Swartz ...
Swartz, Christiane.
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Examining the effect of teaching strategies on student productivity in Moroccan higher education

Discover Education
This study investigates how specific teaching skills impact student learning outcomes. Using a quantitative approach, data were collected from logistics students through a structured survey and analyzed in Python, utilizing techniques such as correlation
Zakaria Elkharmali, Ouail El Kharraz, Abdelhafid Khazzar, Said El-Marzouki, Yasser Lachhab, Kaoutar Chaali   +5 more
doaj   +1 more source

PROJECT FINANCE MECHANISM FOR INVESTMENT PROJECT REALIZATION

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
This article focuses on project finance analysis, one of the most effective mechanisms to accumulate different financial resources in order to implement investment projects.
V. V. Pereverzeva
doaj   +1 more source

Applications of Explainable Artificial Intelligence in Finance—a systematic review of Finance, Information Systems, and Computer Science literature

Management Review Quarterly, 2023
AbstractDigitalization and technologization affect numerous domains, promising advantages but also entailing risks. Hence, when decision-makers in highly-regulated domains like Finance implement these technological advances—especially Artificial Intelligence—regulators prescribe high levels of transparency, assuring the traceability of decisions for ...
Patrick Weber, K. Valerie Carl, Oliver Hinz   +2 more
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

International Islamic finance [PDF]

, 1990
Islamic Banking has both classical and modern connections. Guidelines to acceptable behaviour with regard to money and property were offered in the Quran whilst the compilation of further material and its interpretation is a process that began with the ...
Firth, David M.A.
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