Results 21 to 30 of about 5,406,248 (312)

Approaches to developing mechanisms for medical care centralization at the interterritorial level

Фармакоэкономика
Background. As new high-tech methods of treatment and diagnostics are introduced into the basic compulsory health insurance program, the focus on creating separate regional healthcare systems is becoming less effective.
D. V. Fedyaev, F. S. Nikitin, S. A. Kovaleva, V. V. Omelyanovskiy   +3 more
doaj   +1 more source

Standardized methodology for calculating the cost of medical care funded by government sources

Фармакоэкономика
Background. Current challenges in healthcare include an increase in life expectancy and in medical care (MC) needs, thereby putting pressure on the limited resources of the Russian healthcare system.
M. A. Sdvizhkova, S. A. Kovaleva, D. V. Fedyaev, V. V. Omelyanovskiy   +3 more
doaj   +1 more source

Big data and analytics for crop yield forecasting: Empirical research and development prospects [PDF]

E3S Web of Conferences
The study provides a comprehensive analysis of the role and prospects of applying big data technologies in agriculture. It covers a wide range of issues related to the implementation and use of Big Data in the agro-industrial sector, exploring both the ...
Shvets Yury, Morkovkin Dmitry, Chupin Alexander, Ostroumov Vladimir, Shmanev Sergey   +4 more
doaj   +1 more source

A Hardware Efficient Random Number Generator for Nonuniform Distributions with Arbitrary Precision

International Journal of Reconfigurable Computing, 2012
Nonuniform random numbers are key for many technical applications, and designing efficient hardware implementations of non-uniform random number generators is a very active research field.
Christian de Schryver, Daniel Schmidt, Norbert Wehn, Elke Korn, Henning Marxen, Anton Kostiuk, Ralf Korn   +6 more
doaj   +1 more source

Public control and supervision in the economy: theoretical and legal justification

RUDN Journal of Law, 2023
In the context of the rapid processes of economy digitalization and integration, the issues of updating the forms and methods of public law impact on economic relations in the new modern conditions naturally arise.
Saniyat A. Agamagomedova
doaj   +1 more source

The Buffalo Financial Control Board [PDF]

, 2003
The current fiscal crisis of the City of Buffalo arises from and exemplifies the failure of state and local government over many decades to respond adequately to the shift of population, and especially the disproportionate shift of wealth, from the old ...
Magavern, James L
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Practices applied by practitioners to achieve management and financial control during business rescue

Acta Commercii, 2022
Orientation: To resuscitate financially distressed companies in South Africa, business rescue as introduced through the enactment of Chapter 6 of the Companies Act 71 of 2008 requires the business rescue practitioners (BRPs) to take management and ...
Thabang Madigoe, Marius Pretorius
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source