Results 61 to 70 of about 2,027,095 (316)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
MONITORING AS A FORM OF STATE FINANCIAL CONTROL
Гуманитарные и юридические исследования, 2021 The article attempts to explore the category of «monitoring» as a form of state financial control. Currently, the state financial control is undergoing a new legislative and subordinate regulation connected with introduction of new forms in practice. The
D. A. Smirnov, V. A. Melnikova
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The development of financial technology (fintech) has revolutionized how individuals manage their finances, with paylater services emerging as one of the most popular innovations in Indonesia. While offering payment flexibility, uncontrolled use may lead
Nur, Amalia +3 more
core +1 more source
Considerations on the Institutional Independence Statute of the Romanian Court of Accounts [PDF]
Revista de Management Comparat International, 2011 The article is an analysis of the way the principle of independence works at the level of the Romanian Court of Accounts, the institution habilitated by legal provisions to conduct the financial control/audit activity, in order to obtain an assurance ...
Elena–Carmen BRAGADIREANU
doaj
PRINCIPLES OF FINANCIAL CONTROL IN THE FIELD OF PURCHASES AND THEIR LEGAL FIXING
Гуманитарные и юридические исследования, 2021 The main directions of financial control in the field of procurement are determined by the financial and legal policy of the state. Thus, in order to understand the essence of the principles of financial control in the field of procurement, this ...
A. Gladchuk
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Финансы: теория и практикаThe subject of research in this paper is the investor’s risk profile as a characteristic of his behavior in the stock market. The purpose of the study is to assess the investor’s risk profile in the form of a risk ratio in a model with a linear ...
V. A. Gorelik, T. V. Zolotova
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source