Results 41 to 50 of about 332,738 (311)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Current Economic and Financial Crisis – New Issues or Returning to the Old Problems? Paradigms, Causes, Effects and Solutions Adopted [PDF]
Theoretical and Applied Economics, 2011 At the ideological level, the current crisis, as the others in history, has triggered an intellectual debate among several applicable ideas: ultra-liberal theory of the "invisible hand" of Adam Smith, Keynes’s theory of state interventionism and even neo-
Felix TOTIR, Ingrid-Mihaela DRAGOTĂ
doaj +1 more source
Policy Lessons for Macroeconomic and Financial Crisis Management in the Southern and Eastern Mediterranean. CEPS Policy Brief No. 308, 13 December 2013 [PDF]
, 2013 This Policy Brief attempts to draw lessons from the combination of the global financial crisis and the Arab uprisings focusing on the domains related to fiscal, monetary and financial policies. It does so by answering the following questions: What has
De Groen, Willem Pieter, Ayadi, Rym
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
SOLVING PROBLEMS IN THE RUSSIAN IMPORT SUBSTITUTION CONDITIONS OF ECONOMIC SANCTIONS
Модернизация, инновация, развитие, 2015 The article analyzes some problems of the Russian economy, including the problem of import substitution, the possible directions of their solutions, the need to identify priorities and priority sectors in the fi rst place, do not compete on the ...
A. N. Rjahovskaja, D. I. Rjahovskij
doaj
PROGNOSTIGATION OF FINANCIAL CRISIS OF BANK INSTITUTIONS
Aktualʹnì Problemi Rozvitku Ekonomìki Regìonu, 2016 The article investigates forecasting the financial crisis banks. Particular focus on developing an integrated measure of financial condition and scale with which to determine the level of financial condition: stable, pre-crisis, crisis, a deep crisis ...
Vasyl Martynenko
doaj +1 more source
Theoritical Seekings in Macroeconomics
İstanbul İktisat Dergisi, 2020 Dynamics stochastics general equilibrium (DSGE) models are dominant until the 2008 global financial crisis. Although some economists have stated that macroeconomics is a mature science, others believe that macroeconomics that is based on DSGE models has ...
Emre Örün
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source