Results 91 to 100 of about 21,802,454 (391)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Financial Structure and Economic Development [PDF]

International Finance Discussion Papers, 1990
An important challenge to economists is to explain how financial contracts and institutions affect economic growth while simultaneously explaining how economic development elicits the creation and modification of an economy's financial structure. This paper addresses one side of this inherently two-sided issue.
openaire   +2 more sources

Alternative financial service providers and the spatial void hypothesis: the case of New Jersey and Delaware [PDF]

This paper continues the use of the spatial void hypothesis methodology to analyze the location of alternative financial service providers, such as check cashing outlets and pawn shops, in New Castle County, Delaware, and Atlantic, Mercer, Monmouth, and ...
John Wackes, Marvin M. Smith, Tony E. Smith   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Financial Development of the Russian Federation: Problems of Measurement and Evaluation

Финансы: теория и практика
Financial development has a significant impact on the restructuring of the economy, long-term economic growth and improvement of the level and quality of life of the population.
G. G. Gospodarchuk, M. Yu. Postnikov
doaj   +1 more source

Problems and perspectives of smart grids: Intelligent supply networks and Internet of energy [PDF]

E3S Web of Conferences
The integration of intelligent supply networks and the Internet of Energy (IoE) represents a significant transformation in energy systems. This paper examines the evolving role of smart grids, emphasizing the collaborative efforts needed among ...
Korneeva Elena, Orozalieva Akima, Krayneva Raisa   +2 more
doaj   +1 more source

Does geopolitical risk and financial development matter for economic growth in MENA countries? [PDF]

, 2021
Hassen Soltani, M. Triki, Mohamed Ghandri, Fouzi Abderzag   +3 more
openalex   +1 more source

Financial Development: Maturing and Emerging Policy Issues

The World Bank Research Observer, 2007
In recent decades, financial development policies in emerging market economies have been shaped by a fundamental shift toward market-based financial systems and the lessons from financial crises. Today, there is consensus that financial development depends on financial stability and convergence toward international standards.
de la Torre, Augusto, Gozzi, Juan Carlos, Schmukler, Sergio L.   +2 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The impact of ESG performance on R&D investment stability: Evidence from China

International Review of Economics & Finance
This study investigates how Environmental, Social, and Governance (ESG) performance influences corporate R&D stability. Based on Chinese A-share listed firms, we find that ESG performance mitigates the effect of market shocks on R&D activities ...
Che Chen, Song Chen, Dingwen Wu
doaj   +1 more source