Results 61 to 70 of about 6,023,927 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Financial development, financial fragility, and growth [PDF]

The authors study the apparent contradiction between two strands of the literature on the effects of financial intermediation on economic activity. On the one hand, the empirical growth literature finds a positive effect of financial depth as measured by,
Loayza, Norman, Ranciere, Romain
core   +3 more sources

The Significance of Economic and Environmental Sustainability Management in the Operations of Russian Manufacturing Enterprises [PDF]

E3S Web of Conferences
In contemporary circumstances, it is evident that the activities of industrial enterprises, particularly in the Russian economic system, have a substantial and detrimental impact on the environment.
Vladimirovich Khachaturyan Mikhail, Valeryenva Klicheva Evgeniia   +1 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

ANALYSIS OF LABOR AND LEISURE PRACTICES OF SHADOW SELF-EMPLOYED IN THE PHYSICAL LABOR MARKET IN RUSSIA

Вестник университета, 2021
Blue-collar self-employment occupies about 23 – 25 % in the structure of the Russian economy and is the most difficult for sociological analysis due to its isolation from the outside world. The most acceptable methods of sociological analysis of the self-
I. A. Yurasov, M. A. Tanina, V. A. Yudina, E. V. Kuznetsova   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

NutBaaS: A Blockchain-as-a-Service Platform

IEEE Access, 2019
Blockchain, originated from Bitcoin system, has drawn intense attention from the academic community because of its decentralization, persistency, anonymity and auditability.
Weilin Zheng, Zibin Zheng, Xiangping Chen, Kemian Dai, Peishan Li, Renfei Chen   +5 more
doaj   +1 more source

Financial development and economic growth in an oil-rich economy: The case of Saudi Arabia [PDF]

, 2013
© 2014 Elsevier B.V.We investigate the effect of financial development on economic growth in the context of Saudi Arabia, an oil-rich economy. In doing so, we distinguish between the effects of financial development on the oil and non-oil sectors of the ...
Abu-Bader, Agung, Al-Hassan, Al-Malkawi, Al-Yousif, Ang, Ang, Anon, Ariss, Asterious, Atje, Banerjee, Barajas, Beck, Berthelemy, Buffie, Choudhury, Christopoulos, De Gregorio, Demetriades, Demirguc-Kunt, Enders, Engle, Fosu, Fry, Galbis, Ghatak, Goldsmith, Gonzalo, Greenwood, Greenwood, Hendry, Hicks, Hondroyiannis, Hosein, Inder, Jalil, Jan Fidrmuc, Johansen, Johansen, Khan, King, Kuznets, Levine, Levine, Levine, Long, Lucas, Luintel, Lyons, Mahran, Majid, McKinnon, Mohamad, Muhsin, Murinde, Nahla Samargandi, Nankani, Nili, Odedokun, Patrick, Pesaran, Pesaran, Qi, Ram, Robinson, Sachs, Safdari, Shaw, Shrestha, Singh, Stern, Sugata Ghosh, Thakor, Thangavelu, van der Ploeg, Van Wijnbergen, Woo, Wood   +78 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Social insurance reform and corporate environmental Investments: Evidence from China

International Review of Economics & Finance
This study examines the impact of social insurance contributions on corporate environmental investments, using a sample of 1684 firms with 18,503 firm-year observations from China's A-share listed companies between 2007 and 2019. Adopting a quasi-natural
Bingcheng Zou, Cheng Xu, Meiting Lu, Song Chen   +3 more
doaj   +1 more source