Results 51 to 60 of about 5,686,554 (263)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

The Usefulness of Financial Statements in Making Financial Diagnosis [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2016
Our research aims to develop an analysis of the usefulness of financial statements and financial investment in making the diagnosis. Financial analysis is by definition an activity that performance condition is diagnosed entity of the financial year ...
Mitica Pepi
doaj  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

FINANCIAL DIAGNOSIS OF STOCKS [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2014
Financial diagnosis is a part of a company’s general diagnosis. The role of the financial diagnosis is to establish the situation of the company at a given time, to see if it is viable, to help the decision-makers to take the best measures to continue ...
SUCIU GHEORGHE , BÂRSAN PIPU-NICOLAE
doaj  

Financial Crisis Inquiry Commission

open access: yes, 2011
This website contains the research and final report for the Financial Crisis Inquiry Commission looking at the causes of the economic ...
United States. Financial Crisis Inquiry Commission.
core  

Monetary Financial Institutions ; Annual Review 2014 [PDF]

open access: yes, 2015
The Monetary Financial Institutions – Annual Review focuses on statistics on Finnish monetary financial institutions (MFIs) and investment funds registered in Finland over the previous year.

core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Correlation of the McKinsey 7S Model with the Main Financial Indicators Within an Entity

open access: yesCECCAR Business Review
Financial diagnosis represents an essential component of financial analysis, identifying both the strengths and vulnerabilities of an entity’s activity, while proposing measures to perpetuate favorable elements and improve unfavorable ones.
Bogdan Cosmin GOMOI
doaj   +1 more source

DIAGNOSIS OF FINANCIAL EQUILIBRIUM [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2013
The analysis based on the balance sheet tries to identify the state of equilibrium (disequilibrium) that exists in a company. The easiest way to determine the state of equilibrium is by looking at the balance sheet and at the information it offers ...
SUCIU GHEORGHE
doaj  

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