Results 41 to 50 of about 2,612,458 (300)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Political Economy of Financial Fragility [PDF]
, 2005 Financial liberalization under weak regulatory institutions is often followed by financial crises. We argue that poor regulation may be the deliberate outcome of lobbying interests capturing the reform process. Lobbying on investor protection may be directed at limiting entry, in which case reforms will focus on deepening rather than broadening access ...
Enrico C. Perotti, Erik H. B. Feyen
openaire +5 more sources
BANKING SYSTEM FRAGILITY: CASE OF THE REPUBLIC OF MOLDOVA [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014 The paper studied the determinants of Moldovan banking system fragility. It underlines the existing researches into the empirical determinants of banking fragility.
Dorina CLICHICI
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Bank wholesale funding and credit procyclicality: Evidence from Korea [PDF]
Panoeconomicus, 2013 Credit procyclicality has recently been the focus of considerable attention, but what fuels the often excessive credit growth is rarely questioned.
Jeong Sangjun, Jung Hueechae
doaj +1 more source
Makroekonomik Değişkenlerin Finansal Kırılganlık Üzerine Etkisi
İzmir İktisat Dergisi, 2021 Finansal kırılganlıkların reel sektör üzerinde olumsuz etkilere de neden olabilmesi nedeniyle bu kırılganlıkların öngörülmesi ve önlenebilmesi yönünde çaba sarf edilmesini ve bu amaçla da finansal kırılganlıklarım ele alınmasını gerekli kılmaktadır.
M. Esra Atukalp
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Fragilidad financiera empresarial y expectativas de ingresos: evidencias de un modelo multi-agentes
Cuadernos de Economía, 2018 This paper aims to link the financial fragility of non-financial firms to the way they expect proceeds from their sales: this is then represented in an agent-based macroeconomic model.
Rémi STELLIAN
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source