Results 61 to 70 of about 370,331 (251)

Structural modification of supply chains in the imperatives of circular economy

Journal of Innovation and Entrepreneurship
Global economic and environmental challenges in the development of contemporary society underscore the importance of addressing issues related to the structural modification of supply chains within the context of a circular economy. The goal of the study
Ivan Kudrenko, Almas Mukhametov, Emin Shahin Aslanov   +2 more
doaj   +1 more source

Strategic planning in financial institutions

South African Journal of Business Management, 1982
The article outlines an approach to strategic planning for financial institutions in which functional strategic plans are first developed for each business unit or unique area of service in the organization.
Kenneth C. Krogh
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Determinants of Financial Performance of Non-Bank Financial Institutions: Factoring Institutions in Türkiye

Verimlilik Dergisi
Purpose: Non-bank financial institutions can contribute to the deepening and diversification of financial markets by providing broader access to credit, insurance, and investment services.
Bertaç Şakir Şahin
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Innovative pre-fire alert smart detection system-based embedded system

AIP Advances
Early fire identification is critical to saving lives and property. One viable strategy for improving fire detection systems’ efficacy and precision is the use of Internet of Things (IoT) technology.
Sadeem Marouf Al-Chalabi, Atheer Marouf Al-Chalabi, Rami Ali Al-Khafaji   +2 more
doaj   +1 more source

The heterogeneous effects of artificial intelligence on labor markets: A calibrated simulation of skills, tasks, and wagesZendo

International Review of Economics & Finance
Artificial Intelligence (AI) is reconfiguring labor markets with profound, heterogeneous effects on skills and wages. While existing models offer qualitative insights, they often lack the quantitative rigor for testable predictions. This paper develops a
Abdullah Mohammad Ghazi Al khatib, Bayan Mohamad Alshaib   +1 more
doaj   +1 more source