Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Empirical Research on the Utility of Financial - Accounting Information in Considering Performance for Stakeholders [PDF]
Ovidius University Annals: Economic Sciences Series, 2019 Financial performance is appreciated through the information in the financial statements and a wide range of indicators based on them. A fair financial diagnosis involves a complex analysis of these, but on the other hand each stakeholder category and ...
Mihaela-Maria Mihalcea +1 more
doaj
Predicting Risk from Financial Reports with Regression
North American Chapter of the Association for Computational Linguistics, 2009 We address a text regression problem: given a piece of text, predict a real-world continuous quantity associated with the text's meaning. In this work, the text is an SEC-mandated financial report published annually by a publicly-traded company, and the ...
Shimon Kogan +4 more
semanticscholar +1 more source
Homer Foundation - 2006 Annual Report [PDF]
, 2006 Contains mission statement, board chair's and director's messages, program information, financial statements, reports from the distributions and investment committees, grants list, donors list, and list of board ...
core
Financial bootstrapping and social capital: how technology-based start-ups fund innovation [PDF]
, 2009 Innovation requires more than technological expertise. It is a time consuming activity requiring access to a range of resources including finance. Yet, innovators involved in start-ups rarely have direct access to significant financial resources. Instead,
Audia +24 more
core +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Extra Financial Analysis – EFA: Environmental and financial performances of ABB, Akzo-Nobel and SCA: Picturing the business opportunities and risks associated to stakeholder perceptions and environmental and social prerequisites [PDF]
External assessment of companies’ environmental aspects often focus on the existence of strategies, commitments, management systems and reporting of firms that concerns environmental aspects.
Belhaj, Mohammed, Cerin, Pontus
core
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
, 2018 This paper examines the relationship between corporate social responsibility (CSR) and financial performance for Islamic banks in the Gulf Cooperation Council (GCC) region over the period 2000–2014 by generating CSR-related data through disclosure ...
E. Platonova +3 more
semanticscholar +1 more source
Neutrality of narrative discussion in annual reports of UK listed companies [PDF]
, 2004 This paper reports the results of an investigation into the neutrality of the narrative discussion of financial performance and position, as evidenced in 179 annual reports of UK listed companies.
Accounting Standards Board +14 more
core +1 more source