Results 61 to 70 of about 54,287,348 (354)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
INDICATOR SYSTEM FOR MEASUREMENT OF FINANCIAL AND ECONOMIC ACTIVITIES IN PUBLIC INSTITUTIONS
Baltic Journal of Economic Studies, 2015 The object of the work is study of methods for analyzing the current financial and economic performance of a company as well as the usage of existing methods for the assessment of the company in the current and future periods.
Valeriy Dudnyk, Ludmila Lozovska
doaj
How ordinary consumers make complex economic decisions: financial literacy and retirement readiness [PDF]
, 2009 This paper explores who is financially literate, whether people accurately perceive their own economic decision-making skills, and where these skills come from.
Lusardi, Annamaria, Mitchell, Olivia S.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The accomplishment of family business objectives in the context of the financial results achieved
Forum Scientiae Oeconomia, 2022 The basic condition for the survival and development of each company is the achievement of adequate financial results. This also applies to family businesses, albeit the development and improvement in their market situation must be the most important ...
Magdalena Biel, Oliwia Ślusarczyk
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Eos, Transactions American Geophysical Union, 1982 During the 2‐year period January 1, 1980, through December 31, 1981, the Union's total operations fared quite well. Cumulative revenues were $10,356,500 versus expenses of $10,068,500, generating a $288,000 net increase to the Union's reserve.In actuality, 1981 was a banner year, since its gain from total operations amounted to $422,600, more than ...
openaire +1 more source
Financial health of the higher education sector : 2010-11 financial results and 2011-12 forecasts [PDF]
, 2012 "This report provides an overview on the financial health of the higher education sector in England. The analysis covers the 2010-11 financial results and 2011-12 forecasts, as submitted to HEFCE in early December 2011" - front ...
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source