Results 61 to 70 of about 4,303,369 (356)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Market Microstructure Effects on Firm Default Risk Evaluation
Econometrics, 2016 Default probability is a fundamental variable determining the credit worthiness of a firm and equity volatility estimation plays a key role in its evaluation.
Flavia Barsotti, Simona Sanfelici
doaj +1 more source
Goodness-of-Fit of Logistic Regression of the Default Rate on GDP Growth Rate and on CDX Indices
Mathematics, 2021 Under the Basel II and Basel III agreements, the probability of default (PD) is a key parameter used in calculating expected credit loss (ECL), which is typically defined as: PD × Loss Given Default × Exposure at Default.
Kuang-Hua Hu +3 more
doaj +1 more source
FINANCIAL RISK MANAGEMENT SYSTEM
International Journal of Business, Law and Political Science, 2023 Through the rapid development of the insurance market in Uzbekistan, by the end of 2022, respectively, compared to 2018, the share of insurance services in the gross domestic product (GDP) will be 2.0; the volume of total insurance premiums is 3.3; total assets of insurance organizations 2.1; to increase the number of types of insurance services by 1.7
openaire +1 more source
News Cohesiveness: an Indicator of Systemic Risk in Financial Markets [PDF]
, 2014 Motivated by recent financial crises significant research efforts have been put into studying contagion effects and herding behaviour in financial markets. Much less has been said about influence of financial news on financial markets. We propose a novel
Antulov-Fantulin, Nino +6 more
core +4 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Modifying Sequential Monte Carlo Optimisation for Index Tracking to Allow for Transaction Costs
RisksManaging a portfolio whose value closely tracks an index by trading only in a subset of the index constituents involves an NP-hard optimisation problem.
Leila Hamilton-Russell +3 more
doaj +1 more source
A Risk-Return Paradox: Risk, Performance-Based Pay and Performance [PDF]
, 1993 [Excerpt] In recent years, strategy researchers have examined the relationship between business risk and performance. The logic underlying this relationship is that organizations facing greater business risk seek to offset it with the prospect of higher ...
Bloom, Matthew C. +1 more
core +2 more sources
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Reward-to-risk ratios in Turkish financial markets [PDF]
, 2012 This paper investigates how reward-to-risk ratios compare among various government debt security (GDS) indices and sector indices in the Istanbul Stock Exchange. Risk is measured by either standard deviation or nonparametric and parametric value at risk.
Atilgan, Yigit +3 more
core +1 more source