Results 31 to 40 of about 718,210 (275)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Subsidy and product diversity in the presence of buyer power

open access: yesInternational Studies of Economics, 2022
This paper analyzes the effectiveness of government subsidies in promoting product diversity when a downstream firm has buyer power. Using an extension of the Dixit‐Stiglitz model of monopolistic competition, we compare the effects of subsidies on the ...
Zhiqi Chen, Hong Ding
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Enhancing gender equity in resume job matching via debiasing-assisted deep generative model and gender-weighted sampling

open access: yesInternational Journal of Information Management Data Insights
Our work aims to mitigate gender bias within word embeddings and investigates the effects of these adjustments on enhancing fairness in resume job-matching problems.
Swati Tyagi   +4 more
doaj   +1 more source

Tax wedge in Croatia, Italy, Ireland, the Netherlands and Spain

open access: yesFinancial Theory and Practice, 2016
Each country has a unique tax system, comprising a number of components reflecting the taxation and economic policy of a country. The aim of this paper is to analyse and compare the tax burden on labour income in Croatia, Italy, Spain, Ireland and the ...
Maja Cundić
doaj   +1 more source

Merchant cash advances: investigating the taxation consequences in South Africa

open access: yesJournal of Economic and Financial Sciences, 2015
The merchant cash advance is an emerging lending product designed to address the need to maintain cash flows and is essentially the business equivalent of a “payday” loan.
Eduard Kilian, Rudie Nel
doaj   +1 more source

Evaluating the Heterogeneous Effect of Firm Risk on Firm Value

open access: yesSEISENSE Journal of Management, 2020
Purpose- This paper aims to investigate the effect of firm risk on the firm value to see how the firm value is changing when the risk level is changed. Our result indicates that a higher level of risk can reduce firm value.
Thi Hong Nhung Nguyen
doaj   +1 more source

Relevance of Fair Value Disclosures in Spanish Credit Institutions

open access: yesRevista de Contabilidad: Spanish Accounting Review, 2022
Spanish quoted credit institutions have applied IFRS for their consolidated financial statements since 2005. IFRS implied the implementation of the fair value measurement model for a greater number of financial instruments than previously, as well as ...
David Delgado-Vaquero   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy