Results 41 to 50 of about 3,774,854 (304)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Environmental Sustainability in Practice

, 2017
1. Introduction: What is Environmental Sustainability?2. Sustainability Education3. Environmental Planning and Management4. Sustainable Agriculture5. Geospatial Technologies and Environmental Sustainability6.
Environmental Sustainability Research Centre
core   +1 more source

Structural Determinants of Financial Sustainability of Listed Financial Companies in Nigeria

FUDMA Journal of Accounting and Finance Research (FUJAFR), 2023
The study examined the effect of structural determinant of financial sustainability of listed financial companies in Nigeria from 2012-2021. The study adopted longitudinal research design with panel multiple regression model was used for the analysis ...
Musa Umar Doshiro, Hauwa Victoria Ibrahim, Tanimu Gadi Usman   +2 more
doaj   +1 more source

Determinants of sustainability and organisational effectiveness in non-profit organisations

, 2015
This case study investigates the criteria for organizational effectiveness in non-profit organizations (NPOs) with the aim to determine how the elements of sustainability fit within the criteria. To achieve this, the study utilized the research questions:
Kapondoro, Lloyd, Tengeh, Robertson, Robertson Tengeh, Lloyd Kapondoro, Twum-Darko, Michael, Chux Iwu, Michael Twum-Darko, Iwu, Chux Gervase, Twum-Darko, Dr Michael, Tengeh, Robertson Khan   +9 more
core   +1 more source

Sustainability and Climate Change-related Risk Disclosure in Latin America and the Caribbean: Toward Transparency in Green Financial Markets

, 2023
This paper analyzes the importance of adopting standards for reporting information that relates to sustainability and climate change-related risks in the financial markets. The sustainability rules of the International Financial Reporting Standards (IFRS)
Inter-American Development Bank
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

AUDITING FINANCIAL AND NON-FINANCIAL INFORMATION ON SUSTAINABILITY [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2022
Public interest entities as well as private companies have moved from voluntary reporting to mandatory reporting of financial and non-financial information on environmental, social and governance issues. Basically, new integrated reporting requirements
VICTOR MUNTEANU, ADRIANA HORAICU, ALICE MARIANA PREDA (SIMION),, ANA-MARIA COMÂNDARU (ANDREI),   +3 more
doaj  

Analysis of the Relationship Between Financial Failures and Sustainability Reports of Companies Publishing SASB Reports

İstanbul İktisat Dergisi, 2022
What the relationship is between a company’s sustainability report and its financial performance is a question awaiting an answer. One answer to this question involves determining the place and impact financial sustainability has with regard to overall ...
Buse Öktem, Selahattin Karabınar
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source