Results 71 to 80 of about 12,889 (259)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

How does digital transformation moderate the link between ESG ratings and financial constraints?

Journal of Business Economics and Management
This research aims to examine the moderating role of digital transformation in the link between ESG ratings and financing constraints faced by firms. A sample is a dataset consisting of 4255 listed companies operating in China from 2012 to 2022.
Huiru Chen, Yunhong Hao, Yuan Li, Ahmad Yuosef Alodat   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The impact of directors' information technology experience on the financing constraints of internet start-ups-Data mining with python on the China's New OTC market.

PLoS ONE
In the era of Internet information technology, the IT background of directors plays a significant role in corporate governance. However, existing research lacks sufficient discussion on the financing constraints faced by Internet startups.
Huiji Xu, Senqiang Wang, Jianping Wang, Xiuyu Liu, Kaoxun Chi   +4 more
doaj   +1 more source

The Moderating Role of the Probability of Earnings Manipulation on the Relationship between Financing Constraints and Accounting Information Quality [PDF]

Pizhūhish/hā-yi ḥisābdārī-i mālī
Considering the importance of accounting information quality, this study aims to investigate the moderating role of the probability of earnings manipulation on the relationship between financing constraints and accounting information quality. To test the
Fatemeh Yousefzadeh, Farzad Ghayour, Hamzeh Didar   +2 more
doaj   +1 more source

DIGITAL FINANCE AND ENTERPRISE FINANCING CONSTRAINTS

European Journal of Artificial Intelligence and Digital Economy
In this study, we utilize panel data of A-share listed companies spanning from 2011 to 2020 to examine the effectiveness of the WW index in characterizing the level of enterprise financing constraints in China. Specifically, we explore the impact of regional digital finance (DF) development on these financing constraints. Our findings indicate that the
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Credit reporting and financing constraints [PDF]

The authors combine firm-level data from the World Bank Business Environment Survey (WBES) with data on private and public credit registries to investigate whether the presence of a credit registry in a country is associated with lower financing ...
Inessa Love, Nataliya Mylenko
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Testing financing constraints on firm investment using variable capital [PDF]

We consider a dynamic multifactor model of investment with financing imperfections, adjustment costs and fixed and variable capital. We use the model to derive a test of financing constraints based on a reduced form variable capital equation.
Andrea Caggese
core