Results 141 to 150 of about 690,919 (304)
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Asymmetric Information and Fragility in the South African Low-Income Housing Market [PDF]
This paper focuses on the financing gap in the South African low-income housing market. A model is presented to analyze the effect of asymmetric information on the loan market notably lenders¡¯ need to separate low from high-risk African borrowers.
Laura Ebert
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Sovereign natural disaster insurance for developing countries : a paradigm shift in catastrophe risk financing [PDF]
Economic theory suggests that countries should ignore uncertainty for public investment and behave as if indifferent to risk because they can pool risks to a much greater extent than private investors can. This paper discusses the general economic theory
Ghesquiere, Francis, Mahul, Olivier
core
Influence of spin-off decision on financing risk: Empirical insight from Indonesian Islamic banks. [PDF]
F1000ResPambuko ZB +3 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
THE EFFECTS OF FINANCING SOURCES COSTS OVER THE FINANCIAL AND OPERATIONAL RISK [PDF]
The selection of the financing sources of an enterprise constitutes a major problem for the managerial finance field with influences over the economic-financial performances.
Chirila Emil
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The profitability – risk relationship and financing decision [PDF]
The enterprise financial decision is a rational process for option to the optimal variant related to financing and investments. For the capital investment to be justified, the profitability of the invested money must be at least equal with the ...
Barbuta Misu, Nicoleta
core +1 more source