Results 101 to 110 of about 3,247 (253)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Enhancing the FAIRness of Arctic Research Data Through Semantic Annotation

Data Science Journal
The National Science Foundation’s Arctic Data Center is the primary data repository for NSF-funded research conducted in the Arctic. There are major challenges in discovering and interpreting resources in a repository containing data as heterogeneous and
Steven S. Chong, Mark Schildhauer, Margaret O’Brien, Bryce Mecum, Matthew B. Jones   +4 more
doaj   +1 more source

On making OA data findable

, 2008
Chris Rusbridge, Data, repositories and Google, Digital Curation Blog, March 7, 2008.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Findability of UK health datasets available for research: a mixed methods study

BMJ Health & Care Informatics, 2022
Rebecca M Joseph, Niels Peek, William Dixon, Emily Griffiths, George Tilston, Sarah Thew, Zoher Kapacee   +6 more
doaj   +1 more source

A roadmap for advancing plant phenological studies through effective open research data management

Ecological Informatics
Phenological research, critical for understanding ecological dynamics in response to environmental changes, increasingly relies on Open Research Data Management (ORDM) to enhance scientific outcomes.
Barbara Templ
doaj   +1 more source

Findability catalogue

A publicly available metadata of LONGITOOLS cohorts - the metadata will be published on the LONGITOOLS website, the cluster website and ...
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Information findability: An informal study to explore options for improving information findability for the systems analysis group

, 2014
A Systems Analysis Group has existed at Sandia National Laboratories since at least the mid-1950s. Much of the group’s work output (reports, briefing documents, and other materials) has been retained, along with large numbers of related documents. Over time the collection has grown to hundreds of thousands of unstructured documents in many formats ...
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source