Results 91 to 100 of about 2,307,751 (295)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Interface characteristics of geogrid and gravelly soil by pullout tests

open access: yesYantu gongcheng xuebao
In the field of roadbed engineering, the reinforced gravelly soil filling materials subjected to long-term upper loads are prone to phenomena such as intrusion of fine particles, leading to the deterioration of the mechanical properties at the ...
WANG Jiaquan 1, 2 , LIN Hong 1, 2, WEI Linyi 1, 2, TANG Yi 1, 2
doaj   +1 more source

Dark Energy, with Signatures

open access: yes, 2010
We propose a class of simple dark energy models which predict a late-time dark radiation component and a distinctive time-dependent equation of state $w(z)$ for redshift $z < 3$.
Dutta, Sourish   +2 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pushing the SUSY Higgs mass towards 125 GeV with a color adjoint

open access: yes, 2013
We show that inclusion of a TeV scale chiral superfield transforming in the adjoint representation of the color SU(3) to the MSSM particle content modifies the renormalization group running of some parameters in such a way that a 125 GeV mass of the ...
Bhattacharyya, Gautam   +1 more
core   +1 more source

"DEVELOPMENT OF WOOD GRINDING 5. FINES CONTENT–TO–SHIVES RATIO "

open access: yesCellulose Chemistry and Technology, 2022
"Data by Riissanen were largely applied to learn more about wood grinding and, particularly, possible effects of the moisture content in spruce wood, varying from 65 to 15%, which in terms of moisture ratio covers a range from 1.9 to 0.2 kg water per kg oven dry wood.
openaire   +1 more source

Mechanical properties of coarse-fine particle mixtures: a laboratory investigation of the effect of fine content

open access: yes, 2023
Abstract The impacts of fine content on the microstructure and mechanical behavior of five types of coarse-fine particle mixtures with different fine contents are examined based on laboratory tests. The samples used in these tests all had a void ratio of 0.6.
Liucheng Chang, Ya Wang, Hongyu Wang
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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