Results 101 to 110 of about 321,362 (331)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Existence of infinitely many minimal hypersurfaces in positive Ricci curvature

open access: yes, 2016
In the early 1980s, S. T. Yau conjectured that any compact Riemannian three-manifold admits an infinite number of closed immersed minimal surfaces. We use min-max theory for the area functional to prove this conjecture in the positive Ricci curvature ...
Marques, Fernando C., Neves, Andr'e
core   +1 more source

Globular Clusters as Tracers of Fine Structure in the Dramatic Shell Galaxy NGC 474 [PDF]

open access: bronze, 2017
Sungsoon Lim   +9 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Mechanical strength development of mortars containing volcanic scoria-based binders with different fineness

open access: yesEngineering Science and Technology, an International Journal, 2016
The benefits of using natural pozzolan as cement replacement are often associated with shortcomings such as the need to moist-curing for longer time and a reduction of strength at early ages.
Aref M. al-Swaidani   +2 more
doaj   +1 more source

Harmonia, Melos and Rhytmos. Aristotle on Musical Education [PDF]

open access: yes, 2016
In this paper, I reconstruct the reasons why Aristotle thinks that musical education is important for moral education. Musical education teaches us to enjoy appropriately and to recognize perceptually fine melodies and rhythms.
Cagnoli Fiecconi, Elena
core  

Identification and Characterization of Circular RNAs in Association With the Deposition of Intramuscular Fat in Aohan Fine-Wool Sheep [PDF]

open access: gold, 2021
Le Zhao   +9 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

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