Results 81 to 90 of about 663,341 (297)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Finger Prosthesis Driven by DEA Pairs as Agonist–Antagonist Artificial Muscles

Biomimetics
Loss of an upper limb exerts a negative influence on an individual’s ability to perform their activities of daily living (ADLs), reducing quality of life and self-esteem.
Alexandre B. S. da Silva, Gabriel E. P. Mendes, Eduardo S. Bragato, Guilherme L. Novelli, Marina Monjardim, Rafhael M. Andrade   +5 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

FINGER-elintapaohjelma : toimintamalli kognitiivisen toimintakyvyn tukemiseen [PDF]

, 2019
Suomessa toteutettu FINGER-tutkimus tarjoaa toimintamallin maailmanlaajuisen muistisairausepidemian hillitsemiseksi. Monimuotoinen ohjelma voi pienentää muistihäiriöiden riskiä jopa 30 %. Ohjelman kulmakivet ovat käytännönläheinen ravitsemusohjaus,
Kivipelto, Miia, Solomon, Alina, Kulmala, Jenni, Laatikainen, Tiina, Lehtisalo, Jenni, Antikainen, Riitta, Strandberg, Timo, Paajanen, Teemu, Havulinna, Satu, Soininen, Hilkka, Peltonen, Markku, Lindström, Jaana, Hänninen, Tuomo, Ngandu, Tiia, Rauramaa, Rainer, Tuomilehto, Jaakko   +15 more
core   +2 more sources

Septic Arthritis and Osteomyelitis in Finger Caused by Mycoplasma phocimorsus from Brown Bear, Alaska, USA

Emerging Infectious Diseases
Mycoplasma phocimorsus is an identified zoonotic agent of musculoskeletal infections. Osteomyelitis developed in a patient after injury sustained while skinning a bear, and he experienced delayed diagnosis after ineffective treatments. Clinicians should
Benjamin P. Westley, Alan Swenson, Shanna Berry-Vo, Stephanie Wettin, Daniel R. Brown   +4 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

A rare case: Epidermoid cyst development after groin flap for a fingertip following a gunshot injury

Medicine Science
Pedicled groin flaps are effective surgical techniques used in cases of defective skin injuries on the hand. However, various complications can arise postoperatively.
Ali Canbay, Muhammed Koroglu, Ozlem Dalda, Kadir Ertem   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source