Results 251 to 260 of about 2,198,258 (385)

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

open access: yesAdvanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng   +11 more
wiley   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

open access: yesAdvanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li   +15 more
wiley   +1 more source

Hyperbaric oxygen therapy in managing fingertip injury after the thenar and VY flap procedure: A case series. [PDF]

open access: yesInt J Surg Case Rep
Oley MH   +5 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

open access: yesAdvanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He   +11 more
wiley   +1 more source

Dual‐Working‐Pattern Nanosheet‐Based Hydrogel Sensors for Constructing Human‐Machine and Physiological‐Electric Interfaces

open access: yesAdvanced Science, EarlyView.
Hydrogels hold great potential as candidates for next‐generation epidermal electronics; however, an unresolved issue remains: the differentiation and selection of sensing modes in hydrogel sensors. This study integrates series‐parallel conductive nanosheet configurations into an ultra‐soft hydrogel, resulting in enhanced signal intensity and ...
Shitao Shi   +9 more
wiley   +1 more source

Management of a Rare Case of Complex and Irreducible Dislocation of the Metacarpophalangeal Joint in the Little Finger - A Case Report. [PDF]

open access: yesJ Orthop Case Rep
Panagiotopoulos V   +5 more
europepmc   +1 more source

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