Results 131 to 140 of about 84,152 (317)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

The feasibility for application of DNA fingerprinting to community-level life system

open access: yes, 2004
PCR-based DNA fingerprinting techniques such as random amplified polymorphic DNA analysis( RAPD) represents a very informative and cost-effective approach for assessing genetic diversity of a wide range of organisms.
Yu Yu-He   +3 more
core  

Integrated transcriptomic and proteomic analysis identified key folate biosynthesis gene in waxy maize

open access: yesCrop Journal
One-third of the global population is affected by micronutrient deficiency, particularly folate. Although folate synthesis has been relatively well characterized, few folate-related genes in maize have been cloned, and the molecular mechanism regulating ...
Yanyan Jiao   +13 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

DNA Fingerprinting

open access: yes, 2011
This project was performed to investigate the history and current processes of DNA fingerprinting, and to show how it has affected society. Current types of analyses for DNA fingerprinting were described and discussed.
Tuma, Peter Christopher   +2 more
core  

k-fingerprinting: a Robust Scalable Website Fingerprinting Technique [PDF]

open access: yes, 2016
Website fingerprinting enables an attacker to infer which web page a client is browsing through encrypted or anonymized network connections. We present a new website fingerprinting technique based on random decision forests and evaluate performance over ...
Danezis, G, Hayes, J
core  

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

open access: yesAdvanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet   +8 more
wiley   +1 more source

Fingerprinting

open access: yes, 1991
Two students work on a fingerprinting ...

core  

Firewall fingerprinting [PDF]

open access: yes2012 Proceedings IEEE INFOCOM, 2012
Amir R. Khakpour   +5 more
openaire   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

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