Results 171 to 180 of about 58,596 (248)

Dual-encoder contrastive learning accelerates enzyme discovery. [PDF]

Proc Natl Acad Sci U S A
Rocks JW, Truong DP, Rappoport D, Maddrell-Mander S, Martin-Alarcon DA, Lee TM, Crossan S, Goldford JE.   +7 more
europepmc   +1 more source

Unsupervised Hierarchical Symbolic Regression for Interpretable Property Modeling in Complex Multi‐Variable Systems

Advanced Science, EarlyView.
UHSR translates complex chemical behavior into clear and explainable equations. Applied to thin‐layer chromatography, it automatically uncovers the mathematical rules linking a molecule's structure to its polarity. This approach matches the accuracy of advanced AI while providing interpretable results, earning greater trust from chemists. The method is
Siyu Lou, Chengchun Liu, Dongxiao Zhang, Yuntian Chen, Fanyang Mo   +4 more
wiley   +1 more source

PepFoundry: A Pipeline for Building Machine-Learning Ready Representations of Nonstandard Peptides Containing Cycles, Non-natural Residues, Polymer Units, and More. [PDF]

J Chem Inf Model
Garzon Otero D, Akbari O, Mandapati A, Bilodeau C.   +3 more
europepmc   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Developing a straightforward and robust approach for investigating reservoir compartmentalization based on chemical composition heterogeneities. [PDF]

Sci Rep
Asemani M, Kouhanjani MHS, Rabbani AR.
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Machine Learning Prediction of Analyte-Induced Fluorescence Perturbations in DNA-Functionalized Carbon Nanotubes. [PDF]

Nano Lett
Chakraborty S, Krasley AT, Smith CH, Beyene AG, Vuković L.   +4 more
europepmc   +1 more source

Nonrelativistic Spin Current Generated Unconventional Spin Hall Magnetoresistance in Altermagnetic RuO2

Advanced Science, EarlyView.
It is reported that the unconventional spin Hall magnetoresistance generated from nonrelativistic spin currents in RuO2 is capable of accurately detecting spin current polarization and disentangling the T̂$\hat{T}$‐odd and T̂$\hat{T}$‐even components of a spin current.
Chang Pan, Shuai Hu, Fanli Yang, Dongchao Yang, Wei Zhu, Jianwei Zhang, Weijia Fan, Zhong Shi, Liqing Pan, Shiming Zhou, Xuepeng Qiu   +10 more
wiley   +1 more source

Development of QSAR Models and Web Applications for Predicting hDHFR Inhibitor Bioactivity Using Machine Learning. [PDF]

Molecules
Maattallaoui I, Sakho M, Maatallaoui A, Catalán EB, Aouad NE.   +4 more
europepmc   +1 more source

Redox‐Active NiOx‐Catalyzed Li+ Capture‐Extraction Strategy for tBP‐Free Spiro‐OMeTAD Enables Exceptional Damp‐Heat Stability in Perovskite Solar Cells

Advanced Science, EarlyView.
The redox‐active nature of NiOx enables ultrafast oxidative doping of spiro‐OMeTAD within seconds. Concurrently, NiOx‐Li+ coordination complexes formed during this redox process are selectively removed by filtration, effectively extracting residual Li+ ions from the film.
Yun Seop Shin, Minjin Kim, Jaehwi Lee, Chang Hyeon Yoon, Jongdeuk Seo, Gyeong‐Cheon Choi, Sujung Park, Min Jung Sung, Kyungnan Son, Sungjun Hong, Inyoung Jeong, Junseop Byeon, Yimhyun Jo, Dongmin Lee, Minseong Kim, Shinuk Cho, Ji‐Youn Seo, Jin Young Kim, Dong Suk Kim, SeJin Ahn   +19 more
wiley   +1 more source