Results 1 to 10 of about 614,111 (238)

Hand and foot pressures in the aye-aye (Daubentonia madagascariensis) reveal novel biomechanical trade-offs required for walking on gracile digits [PDF]

, 2010
Arboreal animals with prehensile hands must balance the complex demands of bone strength, grasping and manipulation. An informative example of this problem is that of the aye-aye (Daubentonia madagascariensis), a rare lemuriform primate that is unusual ...
Ancrenaz, Ashton, Cartmill, Cartmill, Cartmill, Curtis, D'Août, Demes, Dutto, Elftman, Erickson, Flannery, Gebo, Hamrick, Hunt, Inouye, Jouffroy, Jouffroy, Jouffroy, Kimura, Kimura, Krakauer, Lammers, Lammers, Lee, Lemelin, Lemelin, Lemelin, Lemelin, Lemelin, Lemelin, Lessertisseur, Milliken, Napier, Napier, Owen, Oxnard, Oxnard, Patel, Patel, Preuschoft, Preuschoft, Prost, Quinn, Raichlen, Raichlen, Reynolds, Richmond, Schaal, Scheumann, Schmitt, Schmitt, Simons, Soligo, Sterling, Strasser, Strasser, Susman, Swartz, Tuttle, Tuttle, Vereecke, Vereecke, Vilensky, Wunderlich, Wunderlich, Wunderlich   +66 more
core   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Anomalous diffusion on a fractal mesh

, 2016
An exact analytical analysis of anomalous diffusion on a fractal mesh is presented. The fractal mesh structure is a direct product of two fractal sets which belong to a main branch of backbones and side branch of fingers.
Iomin, Alexander, Kantz, Holger, Sandev, Trifce   +2 more
core   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Molecular excitation in the Eagle nebula's fingers [PDF]

, 2006
Context: The M16 nebula is a relatively nearby Hii region, powered by O stars from the open cluster NGC 6611, which borders to a Giant Molecular Cloud. Radiation from these hot stars has sculpted columns of dense obscuring material on a few arcmin scales.
Benjamin, Bonatto, C. Hieret, Duchêne, F. Schuller, Hester, K. M. Menten, Keene, L.-Å. Nyman, P. Schilke, Pound, R. Güsten, S. D. Philipp, S. Leurini, Thompson, White, Wilson, Zmuidzinas   +17 more
core   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Preloaded latching device [PDF]

, 1992
A latching device is disclosed which is lever operated sequentially to actuate a set of collet fingers to provide a radial expansion and to actuate a force mechanism to provide a compressive gripping force for attaching first and second devices to one ...
Nagy, Kornel, Wesselski, Clarence J.
core   +1 more source

A comparison of thermographic characteristics of the hands and wrists of rheumatoid arthritis patients and healthy controls [PDF]

, 2019
Thermal imaging has been applied to detect possible temperature variations in various rheumatic disorders. This study sought to determine whether rheumatoid arthritis (RA) patients without active synovitis in their hands exhibit different baseline ...
Borg, Andrew, Camilleri, Liberato, Chockalingam, Nachiappan, Formosa, Cynthia, Gatt, Alfred, Gatt, Corene, Grech, Andrea, Mercieca, Cecilia   +7 more
core   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source